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Merck
CN

A8802

Antide

≥97% (HPLC)

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关于此项目

经验公式（希尔记法）:
C82H108ClN17O14
化学文摘社编号:
112568-12-4
分子量:
1591.29
NACRES:
NA.32
PubChem Substance ID:
24891367
UNSPSC Code:
12352200
MDL number:
MFCD00133104

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InChI key

QRYFGTULTGLGHU-UHFFFAOYSA-N

SMILES string

CC(C)CC(NC(=O)C(CCCCNC(=O)c1cccnc1)NC(=O)C(CCCCNC(=O)c2cccnc2)NC(=O)C(CO)NC(=O)C(Cc3cccnc3)NC(=O)C(Cc4ccc(Cl)cc4)NC(=O)C(Cc5ccc6ccccc6c5)NC(C)=O)C(=O)NC(CCCCNC(C)C)C(=O)N7CCCC7C(=O)NC(C)C(N)=O

InChI

1S/C82H108ClN17O14/c1-50(2)41-65(76(108)95-64(26-11-12-37-88-51(3)4)82(114)100-40-18-27-70(100)81(113)91-52(5)71(84)103)96-75(107)63(25-10-14-39-90-73(105)60-23-17-36-87-48-60)93-74(106)62(24-9-13-38-89-72(104)59-22-16-35-86-47-59)94-80(112)69(49-101)99-79(111)68(45-56-19-15-34-85-46-56)98-78(110)67(43-54-29-32-61(83)33-30-54)97-77(109)66(92-53(6)102)44-55-28-31-57-20-7-8-21-58(57)42-55/h7-8,15-17,19-23,28-36,42,46-48,50-52,62-70,88,101H,9-14,18,24-27,37-41,43-45,49H2,1-6H3,(H2,84,103)(H,89,104)(H,90,105)(H,91,113)(H,92,102)(H,93,106)(H,94,112)(H,95,108)(H,96,107)(H,97,109)(H,98,110)(H,99,111)

assay

≥97% (HPLC)

form

powder

storage temp.

−20°C

Gene Information

rat ... Gnrhr(81668)

Application

Antide has been used as a gonadotropin-releasing hormone (GnRH) antagonist to study its effects on regulating apoptosis in a bovine granulosa cell line (BGC-1) and to determine its GnRH effects on cleavage rates of bovine oocytes in vitro.

Biochem/physiol Actions

Antide is a luteinizing hormone-releasing hormone (LHRH) antagonist with high anti-ovulatory and negligible histamine release activity.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360

Hazard Classifications

Repr. 1B

存储类别

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCC2014
BCBJ6857V
BCBJ6857
BCBG9289V
BCBG9289

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Sarah E A McConnell et al.
Hormones and behavior, 61(4), 479-486 (2012-01-24)
Attempts to determine the influence of testicular hormones on learning and memory in males have yielded contradictory results. The present studies examined whether testicular hormones are important for maximal levels of spatial memory in young adult male rats. To minimize
Ann R Finch et al.
Molecular endocrinology (Baltimore, Md.), 24(2), 423-435 (2009-12-17)
Gonadotropin-releasing hormone acts via cell surface receptors but most human (h) GnRH receptors (GnRHRs) are intracellular. A membrane-permeant nonpeptide antagonist [(2S)-2-[5-[2-(2-axabicyclo[2.2.2]oct-2-yl)-1,1-dimethy-2-oxoethyl]-2-(3,5-dimethylphenyl)-1H-indol-3-yl]-N-(2-pyridin-4-ylethyl)propan-1-amine (IN3)] increases hGnRHR expression at the surface, apparently by facilitating its exit from the endoplasmic reticulum. Here we have
L Simon et al.
International journal of andrology, 35(3), 364-376 (2011-12-14)
We previously reported that oestrogen exposure in neonatal rats induced permanent infertility and malformed penis characterized by fat accumulation, which replaced most of the smooth muscle cells and cavernous spaces in the body of the penis, structures essential for erection.
Marcos García-Juárez et al.
Neuropeptides, 45(1), 63-67 (2010-11-30)
Dose response curves for leptin facilitation of estrous behavior (lordosis and proceptivity) were made by infusing the peptide into the lateral ventricle (icv) of ovariectomized (ovx), ad libitum-fed rats injected 40h previously with 5μg of estradiol benzoate. Leptin doses of
Sarah Dünnhaupt et al.
Journal of controlled release : official journal of the Controlled Release Society, 160(3), 477-485 (2012-05-01)
The aim of the present study was the development and evaluation in vitro as well as in vivo of an oral delivery system based on a novel type of thiolated chitosan, so-called S-protected thiolated chitosan, for the peptide drug antide.
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