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Merck
CN

A8802

Sigma-Aldrich

Antide

≥97% (HPLC)

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关于此项目

经验公式（希尔记法）:
C82H108ClN17O14
化学文摘社编号:
112568-12-4
分子量:
1591.29
MDL编号:
MFCD00133104
UNSPSC代码:
12352200
PubChem化学物质编号:
24891367
NACRES:
NA.32

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方案

≥97% (HPLC)

表单

powder

储存温度

−20°C

SMILES字符串

CC(C)CC(NC(=O)C(CCCCNC(=O)c1cccnc1)NC(=O)C(CCCCNC(=O)c2cccnc2)NC(=O)C(CO)NC(=O)C(Cc3cccnc3)NC(=O)C(Cc4ccc(Cl)cc4)NC(=O)C(Cc5ccc6ccccc6c5)NC(C)=O)C(=O)NC(CCCCNC(C)C)C(=O)N7CCCC7C(=O)NC(C)C(N)=O

InChI

1S/C82H108ClN17O14/c1-50(2)41-65(76(108)95-64(26-11-12-37-88-51(3)4)82(114)100-40-18-27-70(100)81(113)91-52(5)71(84)103)96-75(107)63(25-10-14-39-90-73(105)60-23-17-36-87-48-60)93-74(106)62(24-9-13-38-89-72(104)59-22-16-35-86-47-59)94-80(112)69(49-101)99-79(111)68(45-56-19-15-34-85-46-56)98-78(110)67(43-54-29-32-61(83)33-30-54)97-77(109)66(92-53(6)102)44-55-28-31-57-20-7-8-21-58(57)42-55/h7-8,15-17,19-23,28-36,42,46-48,50-52,62-70,88,101H,9-14,18,24-27,37-41,43-45,49H2,1-6H3,(H2,84,103)(H,89,104)(H,90,105)(H,91,113)(H,92,102)(H,93,106)(H,94,112)(H,95,108)(H,96,107)(H,97,109)(H,98,110)(H,99,111)

InChI key

QRYFGTULTGLGHU-UHFFFAOYSA-N

基因信息

rat ... Gnrhr(81668)

Amino Acid Sequence

Ac-Ala-Phe-Ala-Ser-Lys-Lys-Leu-Lys-Pro-Ala-NH2

应用

Antide has been used as a gonadotropin-releasing hormone (GnRH) antagonist to study its effects on regulating apoptosis in a bovine granulosa cell line (BGC-1) and to determine its GnRH effects on cleavage rates of bovine oocytes in vitro.

生化/生理作用

Antide is a luteinizing hormone-releasing hormone (LHRH) antagonist with high anti-ovulatory and negligible histamine release activity.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360

预防措施声明

P201 - P308 + P313

危险分类

Repr. 1B

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCC2014
BCBJ6857V
BCBJ6857
BCBG9289V
BCBG9289

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Cecily V Bishop et al.
Molecular human reproduction, 15(3), 181-193 (2009-01-27)
This study was designed to provide a genome-wide analysis of the effects of luteinizing hormone (LH) versus steroid ablation/replacement on gene expression in the developed corpus luteum (CL) in primates during the menstrual cycle. On Days 9-11 of the luteal
Takafumi Kawai et al.
Journal of neurophysiology, 104(6), 3540-3550 (2010-10-22)
Gonadotropin-releasing hormone (GnRH) is well known as a hypophysiotropic hormone that is produced in the hypothalamus and facilitates the release of gonadotropins from the pituitary gonadotropes. On the other hand, the functions of extrahypothalamic GnRH systems still remain elusive. Here
A Ljungqvist et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(21), 8236-8240 (1988-11-01)
Antide is the decapeptide N-Ac-D-Nal(2),D-Phe(pCl),D-Pal(3),Ser,Lys(Nic),D-Lys(Nic),Leu,Lys(iPr),P ro,D- Ala-NH2 [Nal(2) represents 3-(2-naphthyl)alanine; Phe(p-Cl) represents 3-(4-chlorophenyl)alanine; Pal(3) represents 3-(3-pyridyl)alanine; Lys(Nic) represents N epsilon-nicotinoyllysine; Lys-(iPr) represents N epsilon-isopropyllysine], which is an antagonist of luteinizing hormone-releasing hormone (LHRH), which has high antiovulatory activity, releases negligible
De-Laine M Cyrenne et al.
Hormones and behavior, 60(5), 625-631 (2011-09-17)
Human adolescents exhibit higher levels of novelty-seeking behaviour than younger or older individuals, and novelty-seeking is higher in males than females from adolescence onwards. Gonadal hormones, such as testosterone and estradiol, have been suggested to underlie age and sex difference
Shira G Ziegler et al.
Hormones and behavior, 58(5), 705-713 (2010-08-10)
Though several studies have suggested that estradiol improves hippocampal-dependent spatial memory, the effects of other hormones in the hypothalamic-pituitary-gonadal axis on memory have largely been ignored. Estradiol and luteinizing hormone (LH) are generally inversely related and LH may significantly affect
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