A8861
Aceclofenac
≥98% (HPLC), anti-inflammatory drug, powder
别名:
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester;
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经验公式（希尔记法）:
C16H13Cl2NO4
化学文摘社编号:
分子量:
354.18
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Aceclofenac, ≥98% (HPLC)
SMILES string
OC(=O)COC(=O)Cc1ccccc1Nc2c(Cl)cccc2Cl
InChI key
MNIPYSSQXLZQLJ-UHFFFAOYSA-N
InChI
1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)
assay
≥98% (HPLC)
form
powder
color
off-white to light tan
solubility
DMSO: ≥20 mg/mL
storage temp.
room temp
Quality Level
Gene Information
human ... PTGS2(5743)
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Application
Aceclofenac (ACE) has been used as an internal standard in the in vivo blood-brain barrier assay. It has also been used to study the interaction of ACE with bovine serum albumin (BSA) by using spectroscopic techniques in combination with computational methods.
Biochem/physiol Actions
Aceclofenac is a phenyl acetic acid derivative used for treating symptoms like swelling, tenderness, and stiffness due to muscle-skeletal and bone-related diseases (rheumatoid arthritis, juvenile arthritis, osteoarthritis, and acute gouty arthritis). This compound shows analgesic and antipyretic properties. Aceclofenac suppresses prostaglandin biosynthesis.
Non-steroidal, anti-inflammatory drug (NSAID), with selectivity for COX-2 over COX-1.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
An insight into the binding of aceclofenac with bovine serum albumin at physiological condition: a spectroscopic and computational approach.
Neeraj Dohare et al.
Journal of biomolecular structure & dynamics, 36(2), 398-406 (2017-01-25)
Viney Chawla et al.
Colloids and surfaces. B, Biointerfaces, 92, 293-298 (2012-01-10)
Solid lipid nanoparticles (SLN) of aceclofenac were prepared using Taguchi experimental design by Trotta method. The prepared SLN were formulated into a gel preparation, using carbopol 940. Gels were evaluated for drug content, bioadhesion and their stability against change of
Rajesh Katara et al.
Colloids and surfaces. B, Biointerfaces, 103, 455-462 (2012-12-25)
The purpose of this study was to prepare Eudragit RL 100-based nanoparticles of aceclofenac by nanoprecipitation and evaluate the particle size, zeta potential, drug entrapment, particle morphology; in vitro drug release and in vivo efficacy. Change in drug-polymer ratio from
Anil Pareek et al.
The journal of pain : official journal of the American Pain Society, 12(5), 546-553 (2011-02-01)
The efficacy and safety of aceclofenac control release (CR) tablets was compared with conventional aceclofenac tablets in patients with knee osteoarthritis (OA). This was a double-blind, double-dummy, randomized, parallel group multicentric study conducted at 6 centers. Two hundred and eighty
Sandipan Dasgupta et al.
Expert opinion on drug delivery, 10(4), 411-420 (2013-01-16)
The aim of the present study was to investigate the potential of a nanoemulsion for topical delivery of aceclofenac using different excipients having optimum emulsifying ability rather than their solubilizing capacity. The oil-in-water nanoemulsions were prepared by screening the excipients
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