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Merck
CN

A8973

2-花生四烯基甘油

≥98% (HPLC), Endogenous cannabinoid receptor agonist, solution

别名:

2-AG, 2-单花生酰甘油, 2-花生四烯酰甘油, （all-Z）-5,8,11,14-二十碳四烯酸-2-羟基-1-（羟甲基）乙酯

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关于此项目

经验公式（希尔记法）:
C23H38O4
化学文摘社编号:
53847-30-6
分子量:
378.55
UNSPSC Code:
12352200
PubChem Substance ID:
24891388
NACRES:
NA.77
MDL number:
MFCD01862600
Assay:
≥98% (HPLC)
Form:
solution
Quality level:
100

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产品名称

2-花生四烯基甘油, ~10 mg/mL, ≥98% (HPLC)

SMILES string

[H]C(CO)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)CO

InChI key

RCRCTBLIHCHWDZ-DOFZRALJSA-N

InChI

1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-

description

9:1 mixture of 2-AG and 1-AG

assay

≥98% (HPLC)

form

solution

drug control

regulated under CDSA - not available from Sigma-Aldrich Canada

concentration

~10 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

Gene Information

human ... FAAH(2166)
rat ... Cnr1(25248), Cnr2(57302)

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相关类别

Biochem/physiol Actions

内源性大麻素受体激动剂。

Physical form

乙腈溶液

Disclaimer

空气敏感

pictograms

FlameExclamation mark
GHS02,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

35.6 °F - closed cup

flash_point_c

2 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

危险化学品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000355963
0000312451
0000355963
0000312451
0000181955

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M Lee et al.
The Journal of pharmacology and experimental therapeutics, 275(2), 529-536 (1995-11-01)
Anandamide (arachidonylethanolamide), isolated from the porcine brain, and 2-arachidonyl-glycerol (2-Ara-Gl), derived from the canine gut, are two recently identified putative endogenous cannabinoid receptor ligands. Both ligands have been reported to possess binding affinity for cannabinoid receptor subtypes, CB1 and CB2.
A F Almeida-Santos et al.
Behavioural brain research, 252, 10-17 (2013-05-30)
Anandamide and 2-arachidonoylglycerol (2-AG) are the two main endocannabinoids, exerting their effects by activating type 1 (CB1r) and type 2 (CB2r) cannabinoid receptors. Anandamide inhibits anxiety-like responses through the activation of CB1r in certain brain regions, including the dorsolateral periaqueductal
Takayuki Sugiura et al.
Progress in lipid research, 45(5), 405-446 (2006-05-09)
2-Arachidonoylglycerol (2-AG) is a unique molecular species of monoacylglycerol isolated in 1995 from rat brain and canine gut as an endogenous ligand for the cannabinoid receptors. 2-AG is rapidly formed from arachidonic acid-containing phospholipids through increased phospholipid metabolism, such as
J Guindon et al.
British journal of pharmacology, 150(6), 693-701 (2006-12-21)
2-arachidonoyl glycerol (2-AG) is an endogenous cannabinoid with central antinociceptive properties. Its degradation is catalysed by monoacylglycerol lipase (MGL) whose activity is inhibited by URB602, a new synthetic compound. The peripheral antinociceptive effects of 2-AG and URB602 in an inflammatory
Ekaterina A Placzek et al.
Neuropharmacology, 55(7), 1095-1104 (2008-09-02)
Anandamide (AEA) and 2-arachidonyl glycerol (2-AG), endogenous ligands for the CB1 and CB2 cannabinoid receptors, are referred to as endocannabinoids because they mimic the actions of delta9-tetrahydrocannabinol (Delta9-THC), a plant-derived cannabinoid. The processes by which AEA and 2-AG are biosynthesized
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