assay
~85% (SDS-PAGE)
form
lyophilized powder
mol wt
28.3 kDa
storage temp.
−20°C
Application
高密度脂蛋白 (HDL) 中的主要蛋白质成分
Biochem/physiol Actions
Apo-AI 约占 HDL 蛋白部分的 70%,是由 245 个氨基酸组成的单一多肽链,其中C 端残基为谷氨酸,N 端残基为天冬氨酸。据报道,分子量为 28.3 kDa。该蛋白由 1 个主要同种型 (pI 5.6) 和 2 个次要同种型(pI 5.53 和 5.46)组成。Apo-AI 显示高含量 α -螺旋结构。α-螺旋结构中的两亲性区域似乎负责脂质结合能力。在水溶液中,Apo-AI 发生自缔合,构象变化较小。Apo-AI 可激活卵磷脂-胆固醇 (LCAT) 酰基转移酶,该酶负责血浆中的胆固醇酯化。
正常血浆 Apo-AI 水平为 90-130 mg/dL。Apo-AI 水平可能与冠状动脉疾病的风险呈负相关。
正常血浆 Apo-AI 水平为 90-130 mg/dL。Apo-AI 水平可能与冠状动脉疾病的风险呈负相关。
激活卵磷脂胆固醇酰基转移酶 (LCAT),负责血浆中胆固醇酯化。
Packaging
Package size based on protein content
Physical form
Lyophilized from 0.01 M ammonium bicarbonate
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Still not finding the right product?
Explore all of our products under 载脂蛋白 A-I 来源于人类血浆
法规信息
新产品
此项目有
Ryan J Henderson et al.
Lipids in health and disease, 8, 27-27 (2009-07-25)
Haptoglobin is a plasma protein that scavenges haemoglobin during haemolysis. Phospholipid Transfer Protein (PLTP) transfers lipids from Low Density Lipoproteins (LDL) to High Density Lipoproteins (HDL). PLTP is involved in the pathogenesis of atherosclerosis which causes coronary artery disease, the