A9329
Aldolase from spinach
lyophilized powder, 0.3-1.0 units/mg protein
别名:
D-果糖-1,6-二磷酸-D-甘油醛-3-磷酸裂解酶
表单
lyophilized powder
比活
0.3-1.0 units/mg protein
运输
dry ice
储存温度
−20°C
一般描述
Aldolase exists in three isoforms namely: ALDOA, ALDOB, and ALDOC. These isoenzymes are differentially expressed in human tissues.
应用
Aldolase from spinach has been used as a standard in electrophoresis for the detection of mesocarp and seed aldolase proteins.
生化/生理作用
Aldolase catalyzes the conversion of fructose 1,6-bisphosphate (F1,6BP) to glyceraldehyde-3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP). It plays a vital role in metabolism and glycolysis. Other than glycolytic enzymes, aldolase also interacts with F-actin, α-tubulin, dynein light chain 8, nexin 9, and phospholipase D2, which indicates its role as a scaffolder and modulator of protein complexes. In addition, it also regulates cell morphology and acidic vesicle trafficking by directly interacting with the ADP-ribosylation factor nucleotide site opener (ARNO). Aldolase may also be involved in the formation of mannoheptulose and perseitol. Increased expression of the protein has been observed in various diseases and cancer types.
分析说明
粗品
Protein determined by Lowry
其他说明
One unit will convert 1.0 μmole of fructose 1,6-diphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate per min at pH 7.4 at 25 °C.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
Yu-Chan Chang et al.
Trends in endocrinology and metabolism: TEM, 29(8), 549-559 (2018-06-17)
The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. However, non-enzymatic
D-mannoheptulose and perseitol in `Hass? avocado: Metabolism in seed and mesocarp tissue
Tesfay SZ , et al.
Southern Medical Journal, 79, 159-165 (2012)
Aldolase directly interacts with ARNO and modulates cell morphology and acidic vesicle distribution.
Maria Merkulova et al.
American journal of physiology. Cell physiology, 300(6), C1442-C1455 (2011-02-11)
Previously, we demonstrated that the vacuolar-type H(+)-ATPase (V-ATPase) a2-subunit functions as an endosomal pH sensor that interacts with the ADP-ribosylation factor (Arf) guanine nucleotide exchange factor, ARNO. In the present study, we showed that ARNO directly interacts not only with
Ipsita Pal-Bhowmick et al.
mBio, 3(5), doi:10-doi:10 (2012-09-20)
Invasion of erythrocytes by Plasmodium falciparum requires a connection between the cytoplasmic tail of the parasite's ligands for its erythrocyte receptors and the actin-myosin motor of the parasite. For the thromobospondin-related anonymous protein (TRAP) ligand on Plasmodium sporozoites, aldolase forms
Veronika Ostatná et al.
Analytica chimica acta, 735, 31-36 (2012-06-21)
In an attempt to develop a label-free electrochemical method for detection of changes in protein structures based on oxidizability of tyrosine and tryptophan residues we tested different types of carbon electrodes. We found that using edge plane pyrolytic graphite electrode
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