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Merck
CN

A9517

偶氮甲烷

13.4 M, >95% (GC)

别名:

AOM

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线性分子式:
CH3N=N(→O)CH3
化学文摘社编号:
分子量:
74.08
UNSPSC Code:
12352103
MDL number:
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InChI key

DGAKHGXRMXWHBX-ONEGZZNKSA-N

InChI

1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+

SMILES string

C\N=[N+](/C)[O-]

assay

>95% (GC)

concentration

13.4 M

solubility

H2O: soluble, ethanol: soluble

storage temp.

−20°C

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Biochem/physiol Actions

诱导DNA中O6-甲基鸟嘌呤加合物的致癌物导致G→A转变。 在实验动物的结肠中诱导肿瘤生成,并用于研究癌症进展和化学预防的机制。
Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.

pictograms

Health hazardSkull and crossbones

signalword

Danger

hcodes

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B

存储类别

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Elham Rouhollahi et al.
Drug design, development and therapy, 9, 3911-3922 (2015-08-08)
Curcuma purpurascens BI. rhizome, a member of the Zingiberaceae family, is a popular spice in Indonesia that is traditionally used in assorted remedies. Dichloromethane extract of C. purpurascens BI. rhizome (DECPR) has previously been shown to have an apoptosis-inducing effect
E Fosslien
Annals of clinical and laboratory science, 30(1), 3-21 (2000-03-18)
Cyclooxygenase (COX)-2 levels are elevated in several types of human cancer tissues. Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both the COX-1 and COX-2 protein, the two enzymes that convert arachidonic acids to prostaglandins. Regular use of such NSAIDs significantly reduces
C W Boone et al.
Cancer research, 50(1), 2-9 (1990-01-01)
A search of the literature using National Library of Medicine databases and individual cancer journal articles yielded over 500 compounds with published chemopreventive activity in animals. From these, an initial 16 agents or agent combinations have been evaluated in the
T Tanaka et al.
Cancer research, 61(6), 2424-2428 (2001-04-06)
The biological role of the peroxisome proliferator-activated receptors (PPARs) in various diseases, including inflammation and cancer, has been highlighted recently. Although PPARgamma ligands have been found to inhibit mammary carcinogenesis in rodents, the effects on colon tumorigenesis are controversial. In

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