InChI key
DGAKHGXRMXWHBX-ONEGZZNKSA-N
InChI
1S/C2H6N2O/c1-3-4(2)5/h1-2H3/b4-3+
SMILES string
C\N=[N+](/C)[O-]
assay
>95% (GC)
concentration
13.4 M
solubility
H2O: soluble, ethanol: soluble
storage temp.
−20°C
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Biochem/physiol Actions
诱导DNA中O6-甲基鸟嘌呤加合物的致癌物导致G→A转变。 在实验动物的结肠中诱导肿瘤生成，并用于研究癌症进展和化学预防的机制。
Induces tumorigenesis in the colon of laboratory animals and is used to study the mechanism of cancer progression and chemoprevention.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral - Carc. 1B
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
E Fosslien
Annals of clinical and laboratory science, 30(1), 3-21 (2000-03-18)
Cyclooxygenase (COX)-2 levels are elevated in several types of human cancer tissues. Nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit both the COX-1 and COX-2 protein, the two enzymes that convert arachidonic acids to prostaglandins. Regular use of such NSAIDs significantly reduces
Elham Rouhollahi et al.
Drug design, development and therapy, 9, 3911-3922 (2015-08-08)
Curcuma purpurascens BI. rhizome, a member of the Zingiberaceae family, is a popular spice in Indonesia that is traditionally used in assorted remedies. Dichloromethane extract of C. purpurascens BI. rhizome (DECPR) has previously been shown to have an apoptosis-inducing effect
C W Boone et al.
Cancer research, 50(1), 2-9 (1990-01-01)
A search of the literature using National Library of Medicine databases and individual cancer journal articles yielded over 500 compounds with published chemopreventive activity in animals. From these, an initial 16 agents or agent combinations have been evaluated in the
T Tanaka et al.
Cancer research, 61(6), 2424-2428 (2001-04-06)
The biological role of the peroxisome proliferator-activated receptors (PPARs) in various diseases, including inflammation and cancer, has been highlighted recently. Although PPARgamma ligands have been found to inhibit mammary carcinogenesis in rodents, the effects on colon tumorigenesis are controversial. In
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