重组
expressed in E. coli
方案
>80% (SDS-PAGE)
表单
buffered aqueous solution
分子量
predicted mol wt 32 kDa
纯化方式
immobilized metal affinity chromatography (IMAC)
浓度
≥0.5 mg/mL
免疫原序列
SETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
基因组数据库 |人类登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... CHRM1(1128)
一般描述
Recombinant protein fragment of Human CHRM1 with N-terminal His6ABP (ABP = Albumin Binding Protein derived from Streptococcal Protein G) fusion tag. Cholinergic receptor, muscarinic 1 (CHRM1) is also known as muscarinic acetylcholine receptor M1 (mAChRs). It encoded by gene CHRM1 located on human chromosome 11q12.3. Cholinergic receptor, muscarinic 1 (CHRM1) belongs to G protein-coupled receptors and comprises of 5 subtypes: M1 to M5.
应用
Suitable as a blocking agent using corresponding antibodies.
生化/生理作用
CHRM1 is activated by acetylcholine and it regulates multitude of physiological processes of the central and peripheral nervous system. It is also associated with learning, cognition and memory. CHRM1 is allosterically regulated and is a prime target for drug design in disorders of central nervous system. CHRM1 receptor modulation improves cognitive function. Elevated levels of CHRM1- acetylcholine complex is observed in patients with Alzheimer′s disease. Single polynucleotide polymorphisms in CHRM1 is observed in patients with schizophrenia. Mutations in the CHRM1 gene locus is associated with facial impairment and developmental delay.
外形
Solution in 1 M urea-PBS, pH 7.4
制备说明
The protein solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user.
其他说明
Corresponding Antibody HPA014101.
法律信息
Prestige Antigens is a trademark of Sigma-Aldrich Co. LLC
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Muscarinic acetylcholine receptors: novel opportunities for drug development
Kruse AC, et al.
Nature Reviews Drug Discovery, 13(7), 549-549 (2014)
Changes of several brain receptor complexes in the cerebral cortex of patients with Alzheimer disease: probable new potential pharmaceutical targets
Falsafi SK, et al.
Amino Acids, 46(1), 223-233 (2014)
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning
Shirey JK, et al.
The Journal of Neuroscience, 29(45), 14271-14286 (2009)
The effect of a muscarinic receptor 1 gene variant on grey matter volume in schizophrenia
Cropley VL, et al.
Psychiatry research. Neuroimaging, 234(2), 182-187 (2015)
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development
Wess J, et al.
Nature Reviews Drug Discovery, 6(9), 721-721 (2007)
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