生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
41 kDa
种属反应性
mouse, human, sheep, bovine, rat, dog, pig
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... FOS(2353)
一般描述
c-Fos is an inducible transcription factor and a functional marker of activated neurons. It is induced in response to neurotransmitters and growth factors.
免疫原
Synthetic peptide directed towards the C terminal region of human FOS
应用
Anti-FOS produced in rabbit is suitable for western blotting at a concentration of 1.25 μg/ml.
生化/生理作用
c-Fos is a trans-acting factor that does not directly bind DNA. It interacts with AP-1 transcription factor, a step that is prerequisite for c-Fos-mediated gene expression. The role of c-Fos has been studied in activation of neurons, oncogenesis and inflammation of bone and skin.
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
其他说明
Synthetic peptide located within the following region: CTPSCTAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLA
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
R Chiu et al.
Cell, 54(4), 541-552 (1988-08-12)
Cell lines stably transfected with metal inducible, MT-fos chimeric genes were used to study the ability of the c-fos gene product, Fos, to act as a transcriptional trans-activator. In 3T3MTfos cells, induction of Fos expression led to specific trans-activation of
Rainer Zenz et al.
Arthritis research & therapy, 10(1), 201-201 (2008-01-30)
Activator protein 1 (AP-1) (Fos/Jun) is a transcriptional regulator composed of members of the Fos and Jun families of DNA binding proteins. The functions of AP-1 were initially studied in mouse development as well as in the whole organism through
K J Kovács
Neurochemistry international, 33(4), 287-297 (1998-12-05)
This article summarizes the achievements that have been accumulated about the role of c-Fos as a transcription factor and as a functional marker of activated neurons. Since its discovery, more than a decade ago, as an inducible immediate-early gene encoding
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