AV31513
Anti-RIPK3 antibody produced in rabbit
IgG fraction of antiserum
别名:
Anti-RIP3, Anti-RIP3beta, Anti-RIP3gamma, Anti-Receptor-interacting serine-threonine kinase 3
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
mol wt
57 kDa
species reactivity
horse, rat, bovine, canine, pig, human, mouse
concentration
0.5 mg - 1 mg/mL
technique(s)
immunohistochemistry: suitable, western blot: suitable
NCBI accession no.
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... RIPK3(11035)
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General description
Rabbit polyclonal anti-RIPK3 antibody reacts with mouse, bovine, canine, and human receptor-interacting serine-threonine kinase 3 kinases.
Receptor-interacting serine-threonine kinase 3 (RIPK3, RIP3β, RIP3gamma) is a key signaling molecule in the programmed necrosis (necroptosis) pathway. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and it is involved in the regulation of (tumor necrosis factor (TNF)-related apoptosis inducing ligand) TRAIL-induced apoptosis.
Immunogen
The immunogen for anti-RIPK3 antibody: synthetic peptide derected towards the N terminal of human RIPK3
Application
Anti-RIPK3 antibody has been used for the studying the role of RIPK3 in necroptosis. The antibody can be used for western blot (1.25μg/ml) and IHC (4-8μg/ml, using paraffin-embedded tissues) applications.
Rabbit polyclonal anti-RIPK3 antibody is used to tag receptor-interacting serine-threonine kinase 3 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of receptor-interacting serine-threonine kinase 3 apoptosis pathways.
Physical form
Lyophilized from PBS buffer with 2% sucrose
Other Notes
Synthetic peptide located within the following region: GGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAG
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Linde Duprez et al.
The Journal of biological chemistry, 287(18), 14863-14872 (2012-03-01)
Receptor-interacting protein kinase 1 (RIPK1) is an important component of the tumor necrosis factor receptor 1 (TNFR1) signaling pathway. Depending on the cell type and conditions, RIPK1 mediates MAPK and NF-κB activation as well as cell death. Using a mutant
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