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Merck
CN

AV32037

Sigma-Aldrich

Anti-NEUROD2 (AB2) antibody produced in rabbit

IgG fraction of antiserum

别名:

Anti-Neurogenic differentiation 2

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关于此项目

UNSPSC代码:
12352203
NACRES:
NA.41
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生物来源

rabbit

偶联物

unconjugated

抗体形式

IgG fraction of antiserum

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

41 kDa

种属反应性

human, dog, bovine, mouse, rat, horse

浓度

0.5 mg - 1 mg/mL

技术

western blot: suitable

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

基因信息

human ... NEUROD2(4761)

一般描述

Neurogenic differentiation 2 (NEUROD2), a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins, is an E-box binding transcription factor that can induce transcription from neuron-specific promoters. NEUROD2 which helps determine neuronal cell fates induces neurogenic differentiation in non-neuronal cells.
Rabbit polyclonal anti-NEUROD2 antibody reacts with bovine, canine, human, mouse, and rat neurogenic differentiation 2 transcription factors.

免疫原

Synthetic peptide directed towards the N terminal region of human NEUROD2

应用

Rabbit Anti-NEUROD2 (AB2) antibody can be used for western blotting assays at a concentration of 0.5μg/ml. The antibody has been used for immunohistochemistry assays.
Rabbit polyclonal anti-NEUROD2 antibody is used to tag neurogenic differentiation 2 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of neurogenic differentiation 2 in neuronal cell determination and differentiation.

生化/生理作用

NEUROD2 is a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of NEUROD2 can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. NEUROD2 can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box. The product of the human gene can induce neurogenic differentiation in non-neuronal cells in Xenopus embryos, and is thought to play a role in the determination and maintenance of neuronal cell fates.

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

其他说明

Synthetic peptide located within the following region: AEVKEEGELGGEEEEEEEEEEGLDEAEGERPKKRGPKKRKMTKARLERSK

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Dominique Bröhl et al.
Developmental biology, 322(2), 381-393 (2008-08-30)
Dorsal horn neurons express many different neuropeptides that modulate sensory perception like the sensation of pain. Inhibitory neurons of the dorsal horn derive from postmitotic neurons that express Pax2, Lbx1 and Lhx1/5, and diversify during maturation. In particular, fractions of
Yasutaka Sugimoto et al.
Cell biology international, 33(2), 174-179 (2008-11-11)
A basic helix-loop-helix transcriptional factor, NeuroD2, plays important roles in neuronal differentiation and survival. We introduced the tetracycline-dependent NeuroD2 expression system to embryonic stem (ES) cells and studied the role of NeuroD2 in the neuronal differentiation. The addition of doxycycline

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