AV38735
Anti-CITED2 (AB2) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2, Anti-MRG1, Anti-P35SRJ
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
28 kDa
species reactivity
human, sheep, mouse, rat, pig, bovine, dog
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CITED2(10370)
Immunogen
Synthetic peptide directed towards the N terminal region of human CITED2
Biochem/physiol Actions
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 (CITED2) is a transcriptional modulator that inhibits the transactivation of HIF1A-induced genes. It is required for the regulation of glycolysis in adult hematopoietic stem cells. Mutations and hypermethylation of CITED2 gene has been implicated in pediatric congenital heart disease. CITED2 acts as a molecular switch of TGF-α- and -β-induced cell growth.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: ADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNAL
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Jinwei Du et al.
Stem cells and development, 23(2), 83-94 (2013-10-03)
Mammalian adult hematopoietic stem cells (HSCs) reside in the hypoxic bone marrow microenvironment and display a distinct metabolic phenotype compared with their progenitors. It has been proposed that HSCs generate energy mainly through anaerobic glycolysis in a pyruvate dehydrogenase kinase
Min Xu et al.
Journal of biomedical science, 21, 7-7 (2014-01-25)
The occurrence of Congenital Heart Disease (CHD) is resulted from either genetic or environmental factors or the both. The CITED2 gene deletion or mutation is associated with the development of cardiac malformations. In this study, we have investigated the role
Y-T Chou et al.
Cell death and differentiation, 19(12), 2015-2028 (2012-07-21)
Transforming growth factor-α (TGF-α)-induced proliferation and transforming growth factor-β (TGF-β)-mediated quiescence are intricately balanced in normal lung-tissue homeostasis but are deregulated during neoplastic progression of lung cancer. Here, we show that Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2), a
Zhan Yin et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(16), 10488-10493 (2002-08-01)
Cited2 is a cAMP-responsive element-binding protein (CBP)/p300 interacting transcriptional modulator and a proposed negative regulator for hypoxia-inducible factor (HIF)-1alpha through its competitive binding with HIF-1alpha to CBP/p300. Disruption of the gene encoding Cited2 is embryonic lethal because of defects in
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