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Merck
CN

AV40173

Sigma-Aldrich

抗-ACTB 兔抗

affinity isolated antibody, lyophilized powder

别名:

Actb Antibody, Actb Antibody - Anti-ACTB antibody produced in rabbit, Anti-Actin, β, Anti-Beta-actin, Anti-PS1TP5BP1

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UNSPSC代码:
12352203
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生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

lyophilized powder

种属反应性

human

技术

western blot: suitable

免疫原序列

GRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIVTNWDDMEKI

NCBI登记号

UniProt登记号

储存温度

−20°C

基因信息

human ... ACTB(60)

一般描述

Actin, a highly conserved protein, is a major component of both the cytoskeletal and contractile structures in all cell types. It varies in amount, being related to the type of differentiation and to the functional state of cells and tissues. Actin can be found in two different forms of aggregation, the globular or the fibrillar state, and at least six distinct isoforms occur in vertebrates. The actins exhibit over 90% sequence homology, but each isoform has a unique NH2-terminal sequence. The isoforms are comprised of three α actins (skeletal, cardiac, smooth), one β actin (β-non-muscle) and two gamma actins (gamma smooth muscle and gamma non-muscle). Difficulties have been encountered in producing polyclonal antibodies due to the highly conserved nature of actin.

免疫原

synthetic peptide corresponding to a region of human ACTB with an internal ID of P22019

应用

β-actin is a nonmuscle actin involved in cytoskeletal structures. Anti-ACTB (anti-β-Actin) is a rabbit IgG polyclonal antibody used to tag β-Actin protein(s) for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques.
Rabbit Anti-ActinB is useful for studying actin structure and function, and to probe binding sites of actin-binding proteins.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

生化/生理作用

Anti-ACTB (anti-β-Actin) antibody recognizes an internal sequence of human β-actin.

外形

Lyophilized from PBS buffer with 2% sucrose

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

13 - Non Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Yueh-Lin Tsai et al.
Scientific reports, 12(1), 8180-8180 (2022-05-18)
Fused in Sarcoma (FUS) is a nuclear RNA/DNA binding protein that mislocalizes to the cytoplasm in the neurodegenerative diseases ALS and FTD. Despite the existence of FUS pathogenic mutations that result in nuclear import defects, a subset of ALS/FTD patients
Megan R Fisher et al.
Journal of immunology (Baltimore, Md. : 1950), 198(7), 2943-2956 (2017-02-19)
Mammalian cells have evolved a common DNA damage response (DDR) that sustains cellular function, maintains genomic integrity, and suppresses malignant transformation. In pre-B cells, DNA double-strand breaks (DSBs) induced at Igκ loci by the Rag1/Rag2 (RAG) endonuclease engage this DDR
Lori A Ehrlich et al.
Cell cycle (Georgetown, Tex.), 14(3), 388-398 (2015-02-07)
T-cell acute lymphoblastic leukemia (T-ALL) is a cancer of immature T cells that exhibits heterogeneity of oncogenic lesions, providing an obstacle for development of more effective and less toxic therapies. Inherited deficiency of ATM, a regulator of the cellular DNA
Julio Castaño et al.
PloS one, 11(2), e0149502-e0149502 (2016-02-20)
The successful use of specialized cells in regenerative medicine requires an optimization in the differentiation protocols that are currently used. Understanding the molecular events that take place during the differentiation of human pluripotent cells is essential for the improvement of
Jing Wang et al.
Molecular medicine reports, 11(5), 3505-3510 (2015-01-13)
A high expression of CD44v6 has been reported in numerous malignant cancers, including stomach, prostate, lung and colon. However, the pathological role and the regulatory mechanisms of CD44v6 have yet to be elucidated. In the present study, the expression levels

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