Anti-ALOX15B antibody produced in rabbit

Arachidonate 15-lipoxygenase, type B (ALOX15B) is an arachidonate metabolizing enzyme that catalyzes the oxidation of arachidonate to (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate (15-HPETE). Arachidonate 15-lipoxygenases and its products are implicated in the pathogenesis of a variety of inflammatory disorders such as arthritis, psoriasis, and asthma.

Synthetic peptide directed towards the C terminal region of human ALOX15B

Anti-ALOX15B polyclonal antibody is used to tag arachidonate 15-lipoxygenase, type B proteins for detection and quantitation by Western blotting and in cells and tissues by immunohistochemical (IHC) techniques. It is used as a probe to study the role of ALOX15B in inflammatory disorders.

ALOX15B is a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively.This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.

Anti-ALOX15B polyclonal antibody reacts with bovine, human, mouse, rat, and canine arachidonate 15-lipoxygenase, type B.

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Synthetic peptide located within the following region: ATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPR

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