AV44552
Anti-CISD2 antibody produced in rabbit
affinity isolated antibody
别名:
Anti-CDGSH iron sulfur domain 2, Anti-ERIS, Anti-Miner1, Anti-WFS2, Anti-ZCD2
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
15 kDa
种属反应性
rabbit, bovine, human, guinea pig, rat, mouse, dog
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CISD2(493856)
免疫原
Synthetic peptide directed towards the N terminal region of human CISD2
应用
Anti-CISD2 antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml.
生化/生理作用
CISD2 (nutrient-deprivation autophagy factor-1, NAF-1) is a zinc finger protein that belongs to the novel Fe-S protein NEET family. It localizes to endoplasmic reticulum and inner mitochondrial membrane and is involved in calcium homeostasis and suppresses beclin-1-dependent autophagy. Mutations in CISD2 gene have been implicated in Wolfram Syndrome 1 and developmental delays.
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
其他说明
Synthetic peptide located within the following region: VLESVARIVKVQLPAYLKRLPVPESITGFARLTVSEWLRLLPFLGVLALL
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Sagi Tamir et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(14), 5177-5182 (2014-04-08)
Life requires orchestrated control of cell proliferation, cell maintenance, and cell death. Involved in these decisions are protein complexes that assimilate a variety of inputs that report on the status of the cell and lead to an output response. Among
Sagi Tamir et al.
PloS one, 8(5), e61202-e61202 (2013-05-30)
Nutrient-deprivation autophagy factor-1 (NAF-1) (synonyms: Cisd2, Eris, Miner1, and Noxp70) is a [2Fe-2S] cluster protein immune-detected both in endoplasmic reticulum (ER) and mitochondrial outer membrane. It was implicated in human pathology (Wolfram Syndrome 2) and in BCL-2 mediated antagonization of
Ai-Gang Sun et al.
Molecular medicine reports, 16(6), 7939-7948 (2017-10-07)
CDGSH iron sulfur domain 2 (CISD2) has been found to be important in carcinogenesis. However, the role of CISD2 in glioma remains to be elucidated. The present study aimed to investigate the role of CISD2 in glioma using the reverse
Melanie A Jones et al.
Biology open, 3(5), 342-352 (2014-04-08)
Wolfram syndrome (WFS) is a progressive neurodegenerative disease characterized by diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. WFS1 and WFS2 are caused by recessive mutations in the genes Wolfram Syndrome 1 (WFS1) and CDGSH iron sulfur domain 2 (CISD2)
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