AV46009
Anti-NCF4 antibody produced in rabbit
affinity isolated antibody
别名:
Ncf4 Antibody, Ncf4 Antibody - Anti-NCF4 antibody produced in rabbit, Anti-MGC3810, Anti-NCF, Anti-Neutrophil cytosolic factor 4, 40 kDa, Anti-P40PHOX, Anti-SH3PXD4
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
39 kDa
种属反应性
human
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NCF4(4689)
一般描述
The previously assigned protein identifier A8K4F9 has been merged into Q15080. Full details can be found on the UniProt database.
免疫原
Synthetic peptide directed towards the N terminal region of human NCF4
应用
Anti-NCF4 antibody produced in rabbit is suitable for western blotting at a concentration of 0.25μg/ml.
生化/生理作用
Anti-NCF4 antibody produced in rabbit is also referred as Anti-Neutrophil cytosolic factor 4, 40kDa, Anti-SH3PXD4 or Anti-P40PHOX.
P40PHOX is a cytosolic component of the activation complex NADPH oxidase that regulates membrane translocation of p67phox and p47phox through the PB1-PC interaction. It facilitates production of superoxide, a multicomponent enzyme system important for host defense. The Px domain of the protein interacts with lipid products of PI3K proposes its role in PI3 kinase-mediated signaling pathway.
P40PHOX is a cytosolic component of the activation complex NADPH oxidase that regulates membrane translocation of p67phox and p47phox through the PB1-PC interaction. It facilitates production of superoxide, a multicomponent enzyme system important for host defense. The Px domain of the protein interacts with lipid products of PI3K proposes its role in PI3 kinase-mediated signaling pathway.
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
其他说明
Synthetic peptide located within the following region: SKYLIYRRYRQFHALQSKLEERFGPDSKSSALACTLPTLPAKVYVGVKQE
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase.
Futoshi Kuribayashi et al.
The EMBO journal, 21(23), 6312-6320 (2002-11-29)
Activation of the superoxide-producing phagocyte NADPH oxidase, crucial in host defense, requires the cytosolic proteins p67(phox) and p47(phox). They translocate to the membrane upon cell stimulation and activate flavocytochrome b(558), the membrane-integrated catalytic core of this enzyme system. The activators
F Kanai et al.
Nature cell biology, 3(7), 675-678 (2001-07-04)
PX domains are found in a variety of proteins that associate with cell membranes, but their molecular function has remained obscure. We show here that the PX domains in p47phox and p40phox subunits of the phagocyte NADPH oxidase bind to
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