生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
分子量
65 kDa
种属反应性
mouse, pig, rat, bovine, zebrafish, rabbit, guinea pig, human, horse, canine
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
储存温度
−20°C
基因信息
human ... NOX1(27035)
免疫原
The immunogen for anti-NOX1 antibody: synthetic peptide derected towards the C terminal of human NOX1
应用
Anti-NOX1 antibody produced in rabbit is suitable for western blotting at a concentration of 0.5μg/mL.
生化/生理作用
NOX1 (NADPH oxidase 1) gene encodes for an enzyme that belongs to NADPH oxidase family and is expressed in the colon predominantly in differentiated epithelial cells. It plays a pivotal role in catalyzing the generation of the superoxide ion as well as requires two cytosolic regulators NOXA1 and NOXO1 and Rac1 for its activity. NOX1 is mitogenic and a potent trigger of the angiogenic switch, increasing the vascularity of tumors and inducing molecular markers of angiogenesis. Additionally, NOX1 and NOX2 stimulate neurotoxic activation of microglia suggesting that they play a crucial role during neuroinflammatory states and in amyotrophic lateral sclerosis (ALS).
外形
Lyophilized from PBS buffer with 2% sucrose
其他说明
Synthetic peptide located within the following region: STIATSHPKSVVGVFLCGPRTLAKSLRKCCHRYSSLDPRKVQFYFNKENF
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Biological roles for the NOX family NADPH oxidases.
William M Nauseef
The Journal of biological chemistry, 283(25), 16961-16965 (2008-04-19)
Jack L Arbiser et al.
Proceedings of the National Academy of Sciences of the United States of America, 99(2), 715-720 (2002-01-24)
The reactive oxygen-generating enzyme Nox1 transforms NIH 3T3 cells, rendering them highly tumorigenic and, as shown herein, also increases tumorigenicity of DU-145 prostate epithelial cells. Although Nox1 modestly stimulates cell division in both fibroblasts and epithelial cells, an increased mitogenic
Miklós Geiszt et al.
Journal of immunology (Baltimore, Md. : 1950), 171(1), 299-306 (2003-06-21)
Reactive oxygen species (ROS) serve several physiological functions; in some settings they act in host defense, while in others they function in cellular signaling or in biosynthetic reactions. We studied the expression and function of a recently described source of
Mykola V Tsapenko et al.
American journal of physiology. Renal physiology, 303(12), F1601-F1607 (2012-09-21)
Vascular access dysfunction causes morbidity in hemodialysis patients. This study examined the generation and pathobiological significance of superoxide anion in a rat femoral arteriovenous fistula (AVF). One week after AVF creation, there was increased production of superoxide anion accompanied by
Cyril Chéret et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 28(46), 12039-12051 (2008-11-14)
Reactive oxygen species (ROS) modulate intracellular signaling but are also responsible for neuronal damage in pathological states. Microglia, the resident CNS macrophages, are prominent sources of ROS through expression of the phagocyte oxidase which catalytic subunit Nox2 generates superoxide ion
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