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Merck
CN

AV49035

Sigma-Aldrich

Anti-LTC4S antibody produced in rabbit

IgG fraction of antiserum

别名:

Anti-Leukotriene C4 synthase, Anti-MGC33147

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关于此项目

UNSPSC代码:
12352203
NACRES:
NA.41
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生物来源

rabbit

偶联物

unconjugated

抗体形式

IgG fraction of antiserum

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

16 kDa

种属反应性

dog, horse, bovine, guinea pig, human

浓度

0.5 mg - 1 mg/mL

技术

western blot: suitable

NCBI登记号

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... LTC4S(4056)

免疫原

Synthetic peptide directed towards the N terminal region of human LTC4S

应用

Anti-LTC4S antibody produced in rabbit is suitable for western blotting at a concentration of 2.5μg/ml.

生化/生理作用

Leukotriene C4 synthase (LTC4S) is involved in the biosynthesis of cysteinyl leukotrienes that are important mediators of anaphylaxis and inflammation associated with asthma. Polymorphism in the gene encoding LTC4S is associated with aspirin-induced urticarial.

外形

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

其他说明

Synthetic peptide located within the following region: MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVY

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

12 - Non Combustible Liquids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Damian Niegowski et al.
PloS one, 9(5), e96763-e96763 (2014-05-09)
Leukotriene (LT) C4 synthase (LTC4S) is an integral membrane protein that catalyzes the conjugation reaction between the fatty acid LTA4 and GSH to form the pro-inflammatory LTC4, an important mediator of asthma. Mouse models of inflammatory disorders such as asthma
M Sánchez-Borges et al.
Journal of investigational allergology & clinical immunology, 19(5), 375-382 (2009-10-30)
Cysteinyl leukotriene production seems to be dysregulated in patients with hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). However, the underlying pathogenic mechanisms of these reactions are poorly understood. Previous studies have suggested a role for the A-444C polymorphism

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