生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
16 kDa
种属反应性
dog, horse, bovine, guinea pig, human
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... LTC4S(4056)
免疫原
Synthetic peptide directed towards the N terminal region of human LTC4S
应用
Anti-LTC4S antibody produced in rabbit is suitable for western blotting at a concentration of 2.5μg/ml.
生化/生理作用
Leukotriene C4 synthase (LTC4S) is involved in the biosynthesis of cysteinyl leukotrienes that are important mediators of anaphylaxis and inflammation associated with asthma. Polymorphism in the gene encoding LTC4S is associated with aspirin-induced urticarial.
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
其他说明
Synthetic peptide located within the following region: MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVY
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Damian Niegowski et al.
PloS one, 9(5), e96763-e96763 (2014-05-09)
Leukotriene (LT) C4 synthase (LTC4S) is an integral membrane protein that catalyzes the conjugation reaction between the fatty acid LTA4 and GSH to form the pro-inflammatory LTC4, an important mediator of asthma. Mouse models of inflammatory disorders such as asthma
M Sánchez-Borges et al.
Journal of investigational allergology & clinical immunology, 19(5), 375-382 (2009-10-30)
Cysteinyl leukotriene production seems to be dysregulated in patients with hypersensitivity to aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs). However, the underlying pathogenic mechanisms of these reactions are poorly understood. Previous studies have suggested a role for the A-444C polymorphism
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