AV50490
Anti-SHC1 antibody produced in rabbit
affinity isolated antibody
别名:
Anti-FLJ26504, Anti-SHC, Anti-SHC (Src homology 2 domain containing) transforming protein 1, Anti-SHCA, Anti-p52SHC, Anti-p66, Anti-p66SHC
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
52 kDa
种属反应性
mouse, guinea pig, horse, dog, human, bovine, rat, rabbit
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... SHC1(6464)
免疫原
Synthetic peptide directed towards the C terminal region of human SHC1
应用
Anti-SHC1 antibody produced in rabbit is suitable for western blotting at a concentration of 1.0μg/ml.
生化/生理作用
Src homology 2 domain containing) transforming protein 1 (SHC1; SHC; SHCA) gene encodes three isoforms, p66Shc, p52Shc and p46Shc. p52Shc and p46Shc are involved recruitment of Grb2/Sos complex and activation of Ras pathway. p66Shc is involved in regulating the effects of reactive oxygen species and aging.
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
其他说明
Synthetic peptide located within the following region: AEQLRGEPWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQ
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Alessandra Berry et al.
Neuroscience and biobehavioral reviews, 37(5), 790-802 (2013-03-26)
Life expectancy in the last century has greatly increased although, in most industrialized countries, this has been paralleled by an increased incidence of neurodegenerative disorders, in addition to cardiovascular and metabolic pathologies. The p66(Shc) gene has emerged as a novel
K S Ravichandran
Oncogene, 20(44), 6322-6330 (2001-10-19)
The adapter protein Shc was initially identified as an SH2 containing proto-oncogene involved in growth factor signaling. Since then a number of studies in multiple systems have implicated a role for Shc in signaling via many different types of receptors
Elena De Marchi et al.
Oxidative medicine and cellular longevity, 2013, 564961-564961 (2013-04-23)
Reactive oxygen species (ROS) are a byproduct of the normal metabolism of oxygen and have important roles in cell signalling and homeostasis. An imbalance between ROS production and the cellular antioxidant defence system leads to oxidative stress. Environmental factors and
M Halon et al.
Free radical research, 48(11), 1363-1370 (2014-09-02)
Recently, iron and the adaptor protein "p66Shc" have been shown to play an important role in the development of amyotrophic lateral sclerosis (ALS) in rats. We hypothesized that changes in muscle p66Shc activity and iron metabolism would appear before visible
Santosh Kumar et al.
Biochemical and biophysical research communications, 449(4), 496-501 (2014-05-23)
Hypercholesterolemia leads to a prothrombotic phenotype. Platelet hyperactivity associated with hypercholesterolemia has been attributed, in part, to oxidative stress. P66Shc is a well-known determinant of cellular and organismal oxidative stress. However, its role in platelet biology is not known. We
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