B0686
Anti-BTK, N-Terminal antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Agammaglobulinemia tyrosine kinase (ATK), Anti-Bruton’s tyrosine kinase
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 75 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
microarray: suitable, western blot: 1-2 μg/mL using lysates of Ramos (Human Burkitt lymphoma) cell line
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... BTK(695)
General description
BTK is a tyrosine-protein kinase that modulates signaling, growth, and differentiation in B-lymphocytes. BTK also mediates cytoskeletal rearrangements and associates with Pin1 to regulate the cell-cycle dependent expression of BTK. Additionally, BTK signaling cascades are involved in regulation of calcium fluxes and transcription. Genetic alterations in BTK1 have been linked to X-linked aγglobulinemia . Anti-BTK, N-Terminal antibody is specific for human BTK (75 kDa). In immunoblotting, staining of the BTK band is specifically inhibited by the immunizing peptide.
Immunogen
The immunogen sequence is conserved in mouse, rat and chicken.
synthetic peptide corresponding to amino acids 11-26 of human BTK, conjugated to KLH via a C-terminal added cysteine residue. This sequence differs from the human Tec tyrosine kinase by 2 amino acids.
Application
Anti-BTK, N-Terminal antibody is suitable for use in western blot (1-2 μg/mL using lysates of Ramos (Human Burkitt lymphoma) cell line) and microarray.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
B F Nore et al.
European journal of immunology, 30(1), 145-154 (1999-12-22)
Bruton's tyrosine kinase (Btk) is a member of the Tec family of protein tyrosine kinases (PTK) characterized by an N-terminal pleckstrin homology domain (PH) thought to directly interact with phosphoinositides. We report here that wild-type (wt) and also a gain-of-function
Liang Yu et al.
The Journal of biological chemistry, 281(26), 18201-18207 (2006-04-29)
Bruton tyrosine kinase (Btk) is expressed in B-lymphocytes. Mutations in Btk cause X-linked agammaglobulinemia in humans. However, the mechanism of activation and signaling of this enzyme has not been fully investigated. We have here shown that the peptidylprolyl cis/trans isomerase
Abdalla J Mohamed et al.
Immunological reviews, 228(1), 58-73 (2009-03-18)
Bruton's agammaglobulinemia tyrosine kinase (Btk) is a cytoplasmic tyrosine kinase important in B-lymphocyte development, differentiation, and signaling. Btk is a member of the Tec family of kinases. Mutations in the Btk gene lead to X-linked agammaglobulinemia (XLA) in humans and
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