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B135

R(+)-6-Bromo-APB hydrobromide

solid

别名:

R(+)-6-Bromo-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

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关于此项目

经验公式（希尔记法）:
C19H20BrNO2 · HBr
化学文摘社编号:
139689-19-3
分子量:
455.18
NACRES:
NA.77
PubChem Substance ID:
24277887
UNSPSC Code:
12352200
MDL number:
MFCD00153774
Form:
solid
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form

solid

color

off-white

solubility

ethanol: soluble

storage temp.

2-8°C

SMILES string

Br[H].Oc1cc2[C@H](CN(CCc2c(Br)c1O)CC=C)c3ccccc3

InChI

1S/C19H20BrNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H/t16-;/m1./s1

InChI key

CTAUBYSSTAODOD-PKLMIRHRSA-N

Gene Information

human ... DRD1(1812)

Biochem/physiol Actions

D1 Dopamine receptor agonist; potent enantiomer.

Disclaimer

Photosensitive

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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J L Neumeyer et al.
Journal of medicinal chemistry, 35(8), 1466-1471 (1992-04-17)
Substituted 1-phenyl-3-benzazepines (e.g., SKF 38393 and fenoldopam) exhibit stereoselectivity in moderately high-affinity binding to and partial agonist activation of D1 dopamine receptors. The 3-allyl (APB) and the 3-allyl-6-chloro (6-Cl-APB) analogues of SKF 38393 are reported to have higher affinity and
Jing Yuan et al.
Nature chemical biology, 5(10), 765-771 (2009-09-08)
Studies of gene function and molecular mechanisms in Plasmodium falciparum are hampered by difficulties in characterizing and measuring phenotypic differences between individual parasites. We screened seven parasite lines for differences in responses to 1,279 bioactive chemicals. Hundreds of compounds were
Phedias Diamandis et al.
Nature chemical biology, 3(5), 268-273 (2007-04-10)
The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways that governs the

全球贸易项目编号

货号GTIN
B135-100MG04061832079257
B135-25MG04061832079264

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