B138
BTCP hydrochloride
别名:
Benocyclidine hydrochloride, N-[1-(Benzo[b]thien-2-yl-cyclohexyl)]piperidine hydrochloride
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关于此项目
经验公式（希尔记法）:
C19H25NS · HCl
化学文摘社编号:
分子量:
335.93
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C19H25NS.ClH/c1-5-11-19(12-6-1,20-13-7-2-8-14-20)18-15-16-9-3-4-10-17(16)21-18;/h3-4,9-10,15H,1-2,5-8,11-14H2;1H
SMILES string
Cl[H].C1CCN(CC1)C2(CCCCC2)c3cc4ccccc4s3
InChI key
XBOZTWUGBRZVBP-UHFFFAOYSA-N
form
powder
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada; Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
color
white
solubility
H2O: >180 mg/mL
ethanol: soluble
storage temp.
2-8°C
Gene Information
human ... SLC6A3(6531)
Biochem/physiol Actions
BTCP is a blocker of dopamine transport.
BTCP is a potent and selective blocker of dopamine transport with little affinity for phencyclidine sites.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Robert N Pechnick et al.
Life sciences, 78(17), 2006-2011 (2005-11-18)
Phencyclidine (PCP) activates the hypothalamo-pituitary-adrenal (HPA) axis and decreases plasma prolactin levels in the rat. PCP is a noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist, but it also inhibits the reuptake of dopamine, serotonin and norepinephrine. The purpose of the present study
M E Alburges et al.
Synapse (New York, N.Y.), 14(4), 314-323 (1993-08-01)
Several studies suggest that one of the most important factors contributing to cocaine dependence is an alteration in the actions of the neurotransmitter dopamine in the central nervous system. In order to understand some of the neuroreceptor consequences of cocaine
E P Prinssen et al.
Psychopharmacology, 143(1), 8-14 (1999-05-05)
Because the dopamine reuptake inhibitors cocaine and BTCP produce different behavioral effects after repeated administration, we studied whether they could alter each other's effects by examining the effects of crossing over repeated treatment with cocaine and BTCP on cocaine-induced locomotion.
E D French et al.
Synapse (New York, N.Y.), 13(2), 108-116 (1993-02-01)
Extracellular single-unit recordings were used to assess the effects of PCP and PCP-like drugs (MK-801 and TCP) on the burst firing of ventral tegmental A10 dopamine neurons in the rat. The effects of these noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonists were
T Maurice et al.
Journal of neurochemistry, 56(2), 553-559 (1991-02-01)
The phencyclidine (PCP) derivative, [3H]N-[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine ([3H]BTCP), was used to label in vivo the dopamine uptake complex in mouse brain. The striatum accumulated the highest level of total and specific binding. Drugs which bind to the dopamine uptake site inhibited [3H]BTCP
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