B138
BTCP hydrochloride
别名:
Benocyclidine hydrochloride, N-[1-(Benzo[b]thien-2-yl-cyclohexyl)]piperidine hydrochloride
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关于此项目
经验公式（希尔记法）:
C19H25NS · HCl
化学文摘社编号:
分子量:
335.93
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
powder
InChI
1S/C19H25NS.ClH/c1-5-11-19(12-6-1,20-13-7-2-8-14-20)18-15-16-9-3-4-10-17(16)21-18;/h3-4,9-10,15H,1-2,5-8,11-14H2;1H
SMILES string
Cl[H].C1CCN(CC1)C2(CCCCC2)c3cc4ccccc4s3
InChI key
XBOZTWUGBRZVBP-UHFFFAOYSA-N
form
powder
drug control
regulated under CDSA - not available from Sigma-Aldrich Canada; Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
color
white
solubility
H2O: >180 mg/mL, ethanol: soluble
storage temp.
2-8°C
Gene Information
human ... SLC6A3(6531)
Biochem/physiol Actions
BTCP is a blocker of dopamine transport.
BTCP is a potent and selective blocker of dopamine transport with little affinity for phencyclidine sites.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
X S He et al.
Journal of medicinal chemistry, 36(9), 1188-1193 (1993-04-30)
Piperidine and cyclohexyl ring homologues of the high-affinity dopamine (DA) uptake inhibitor 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine (BTCP, 3) were each prepared in four steps from the appropriate cycloalkanones. These compounds were tested for their ability to displace [3H]BTCP and [3H]cocaine and to inhibit
T Maurice et al.
General pharmacology, 24(1), 191-194 (1993-01-01)
1. [3H]N-[1-(2-Benzo(b)thiophenyl)cyclohexyl]piperidine ([3H]BTCP) labels in vivo the dopamine uptake complex in the mouse striatum. 2. In mice treated with gamma-butyrolactone (GBL, 400 mg/kg), [3H]BTCP specific binding was increased and ID50 values of BTCP and cocaine for the prevention of [3H]BTCP
Charles Hainley et al.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, 67(6), 1071-1073 (2009-03-07)
Methods are described to synthesize and characterize tritium labelled TCP and BTCP at high specific activity.
F Espaze et al.
European journal of medicinal chemistry, 35(3), 323-331 (2000-04-29)
Congeners of the potent dopamine (DA) re-uptake inhibitor 1-[1-(2-benzo[b]thiophenyl)cyclohexyl]piperidine (BTCP) are unexpectedly able to bind in the rat cerebellum, although this structure is devoid of dopaminergic nerve endings. In line with previous studies the hypothesis that they bind to low
X He et al.
Journal of medicinal chemistry, 36(25), 4075-4081 (1993-12-10)
We previously reported (J. Med. Chem. 1993, 36, 1188-1193) that changes to the ring size of the piperidine and cyclohexyl rings of the high-affinity and selective dopamine (DA)-uptake inhibitor 1-[1-(2-benzo[b]thienyl)cyclohexyl]piperidine (BTCP, 2) caused different, and in some cases opposite, changes
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