B141
(±)-4-溴高鹅膏蕈氨酸
solid
别名:
(±)-α-Amino-4-bromo-2,3-dihydro-3-oxo-5-isoxazolepropanoic acid
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关于此项目
经验公式（希尔记法）:
C6H7BrN2O4
化学文摘社编号:
分子量:
251.03
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
产品名称
(±)-4-溴高鹅膏蕈氨酸, solid
InChI
1S/C6H7BrN2O4/c7-4-3(13-9-5(4)10)1-2(8)6(11)12/h2H,1,8H2,(H,9,10)(H,11,12)
SMILES string
NC(CC1=C(Br)C(=O)NO1)C(O)=O
InChI key
JRTOQOAGTSUNHA-UHFFFAOYSA-N
form
solid
color
white
solubility
H2O: moderately soluble
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Biochem/physiol Actions
Potent AMPA receptor agonist
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Mai Marie Holm et al.
Proceedings of the National Academy of Sciences of the United States of America, 102(34), 12053-12058 (2005-08-16)
Glutamate receptors (GluRs) are the most abundant mediators of the fast excitatory neurotransmission in the human brain. Agonists will, after activation of the receptors, induce different degrees of desensitization. The efficacy of agonists strongly correlates with the agonist-induced closure of
T Coquelle et al.
Neuroreport, 11(12), 2643-2648 (2000-09-08)
The lack of subtype-selective compounds for AMPA receptors (AMPA-R) led us to search for compounds with such selectivity. Homoibotenic acid analogues were investigated at recombinant GluR1o, GluR2o(R), GluR3o and GluR1o + 3o receptors expressed in Sf9 insect cells and affinities
T G Banke et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 21(9), 3052-3062 (2001-04-20)
Although GluR1(o) and GluR3(o) are homologous at the amino acid level, GluR3(o) desensitizes approximately threefold faster than GluR1(o). By creating chimeras of GluR1(o) and GluR3(o) and point amino acid exchanges in their S2 regions, two residues were identified to be
Turning behaviour and catalepsy after injection of excitatory amino acids into rat substantia nigra.
J Arnt
Neuroscience letters, 23(3), 337-342 (1981-05-29)
Unilateral injection of AMPA ((R,S)-alpha-3-hydroxyl-5-methyl-4-isoxazolepropionic acid), 4-bromohomoibotenic acid, kainic acid and N-methylaspartic acid into the caudal part of substantia nigra induced ipsilateral turning behaviour. AMPA and kainic acid were most potent. Ibotenic acid produced short-lasting ipsilateral turning followed by long-lasting
D S Chung et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 742-749 (1997-11-14)
Metabotropic glutamate receptors (mGluRs) are a family of glutamate receptors that are coupled to a variety of second messenger systems through GTP-binding proteins. Of the eight subtypes cloned to date, mGluR1 and mGluR5 are coupled to phosphoinositide hydrolysis in expression
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