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Merck
CN

B162

B-HT 920 dihydrochloride

solid, ≥98% (HPLC)

别名:

5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride, Talipexole

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关于此项目

经验公式(希尔记法):
C10H15N3S · 2HCl
化学文摘社编号:
分子量:
282.23
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
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assay

≥98% (HPLC)

form

solid

color

off-white

solubility

H2O: >20 mg/mL

SMILES string

Cl.Cl.Nc1nc2CCN(CCc2s1)CC=C

InChI

1S/C10H15N3S.2ClH/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8;;/h2H,1,3-7H2,(H2,11,12);2*1H

InChI key

DPQAXNSOFFYKDS-UHFFFAOYSA-N

Gene Information

rat ... Drd2(24318)

Biochem/physiol Actions

α2-adrenoceptor agonist; D2 dopamine receptor agonist.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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分析证书(COA)

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K Orito et al.
British journal of pharmacology, 134(4), 763-770 (2001-10-19)
1. Antagonistic properties of OPC-28326 ([4-(N-methyl-2-phenylethylamino)-1-(3,5-dimethyl-4-propionyl-aminobenzoyl)] piperidine hydrochloride monohydrate), a selective peripheral vasodilator, were investigated by analysing the data from functional studies in various tissues from the rat and binding studies of the drug to alpha(2)-adrenoceptor subtypes. 2. Using a
F Ferrari et al.
Life sciences, 70(13), 1501-1508 (2002-03-16)
Two experiments were performed to evaluate the effects of sildenafil on spontaneous or dopamine agonist-induced behaviour in male rats. Data obtained in experiment 1 show that oral administration of the drug, at 1 mg/kg, significantly increased the occurrence of penile
Keiko Shimizu et al.
Neuroscience research, 46(4), 523-532 (2003-07-23)
Paraquat (1,1'-dimethyl-4,4'-bipyridinium, PQ) is a herbicide to possibly induce Parkinson's disease (PD), since a strong correlation has been found between the incidence of the disease and the amount of PQ used. In this study, we examined PQ toxicity in rat
A Gobert et al.
The Journal of pharmacology and experimental therapeutics, 305(1), 338-346 (2003-03-22)
In a dialysis procedure not requiring perfusate addition of acetylcholinesterase inhibitors to "boost" basal levels of acetylcholine (ACh), the influence of the antiparkinson agent piribedil upon levels of ACh in frontal cortex and dorsal hippocampus of freely moving rats was
Postsynaptic dopamine agonist properties of B-HT 920 as revealed by concomitant D-1 receptor stimulation.
C Pifl et al.
European journal of pharmacology, 146(1), 189-191 (1988-01-27)

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