B162
B-HT 920 dihydrochloride
solid, ≥98% (HPLC)
别名:
5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride, Talipexole
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关于此项目
经验公式（希尔记法）:
C10H15N3S · 2HCl
CAS Number:
分子量:
282.23
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
方案
≥98% (HPLC)
表单
solid
颜色
off-white
溶解性
H2O: >20 mg/mL
SMILES字符串
Cl.Cl.Nc1nc2CCN(CCc2s1)CC=C
InChI
1S/C10H15N3S.2ClH/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8;;/h2H,1,3-7H2,(H2,11,12);2*1H
InChI key
DPQAXNSOFFYKDS-UHFFFAOYSA-N
基因信息
rat ... Drd2(24318)
生化/生理作用
α2-adrenoceptor agonist; D2 dopamine receptor agonist.
特点和优势
This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
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Hypertension research : official journal of the Japanese Society of Hypertension, 25(2), 197-202 (2002-06-06)
To investigate the vascular endothelial dysfunction in the insulin resistance syndrome, muscarinic and alpha2-adrenergic mediated relaxations were studied in the fructose-fed rat. Male Sprague-Dawley rats were fed either fructose-rich chow (FFR, n=14) or normal chow (CNT, n=13) for 8 weeks.
Beatriz Civantos et al.
European journal of pharmacology, 489(1-2), 101-110 (2004-04-06)
It has been suggested that the combination of dietary Ca and Ca2+ channel antagonists could have a synergic antihypertensive effect. In this study, 3-week-old male spontaneously hypertensive rats (SHR) were randomized into four groups of animals. Two of these groups
Minori Enomoto et al.
Movement disorders : official journal of the Movement Disorder Society, 23(6), 811-816 (2007-12-13)
This study was done to identify the clinical characteristics of uremic restless legs syndrome (RLS). Consecutive uremic RLS patients (n = 15) and idiopathic RLS patients (iRLS; n = 20) were evaluated. The groups were compared with respect to their
M R Corboz et al.
Pulmonary pharmacology & therapeutics, 21(3), 449-454 (2007-09-18)
The vascular bed in nasal mucosa of different species, including human, is highly vascularized and an extensive sinusoidal network of large capacitance vessels is present deep within the submucosa. When this network of venous sinusoids is engorged with blood, the
R C Miller et al.
British journal of pharmacology, 83(4), 903-908 (1984-12-01)
In the presence of endothelium maximal contractions of rat aorta preparations evoked by B-HT 920 were about 10% of those evoked in the absence of endothelium. 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo-(4,5-d)azepin dihydrochloride (B-HT 920, 0.1 microM to 0.1 mM) induced concentration-dependent contractions of rat
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