B162
B-HT 920 dihydrochloride
solid, ≥98% (HPLC)
别名:
5,6,7,8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4,5-d]azepine-2-amine dihydrochloride, Talipexole
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关于此项目
经验公式（希尔记法）:
C10H15N3S · 2HCl
化学文摘社编号:
分子量:
282.23
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
产品名称
B-HT 920 dihydrochloride, solid, ≥98% (HPLC)
InChI
1S/C10H15N3S.2ClH/c1-2-5-13-6-3-8-9(4-7-13)14-10(11)12-8;;/h2H,1,3-7H2,(H2,11,12);2*1H
SMILES string
Cl.Cl.Nc1nc2CCN(CCc2s1)CC=C
InChI key
DPQAXNSOFFYKDS-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
off-white
solubility
H2O: >20 mg/mL
Gene Information
rat ... Drd2(24318)
Biochem/physiol Actions
α2-adrenoceptor agonist; D2 dopamine receptor agonist.
Features and Benefits
This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Kazuo Yamashiro et al.
Movement disorders : official journal of the Movement Disorder Society, 23(7), 935-941 (2008-04-10)
To investigate the frequency of cardiac valve regurgitation related with low dose dopamine agonists in patients with Parkinson's disease (PD), echocardiograms were analyzed in 527 consecutive PD patients (448 patients treated with dopamine agonists, 79 patients never treated with dopamine
M R Corboz et al.
Pulmonary pharmacology & therapeutics, 20(2), 149-156 (2006-07-01)
Nasal congestion, one of the major disease features of rhinitis, is induced by the filling of venous sinusoids causing mucosal engorgement with resultant obstruction of nasal airflow. The only available drugs that directly target the underlying vascular features driving nasal
M R Corboz et al.
Pulmonary pharmacology & therapeutics, 21(3), 449-454 (2007-09-18)
The vascular bed in nasal mucosa of different species, including human, is highly vascularized and an extensive sinusoidal network of large capacitance vessels is present deep within the submucosa. When this network of venous sinusoids is engorged with blood, the
R C Miller et al.
British journal of pharmacology, 83(4), 903-908 (1984-12-01)
In the presence of endothelium maximal contractions of rat aorta preparations evoked by B-HT 920 were about 10% of those evoked in the absence of endothelium. 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo-(4,5-d)azepin dihydrochloride (B-HT 920, 0.1 microM to 0.1 mM) induced concentration-dependent contractions of rat
Yoshitoki Takagawa et al.
Hypertension research : official journal of the Japanese Society of Hypertension, 25(2), 197-202 (2002-06-06)
To investigate the vascular endothelial dysfunction in the insulin resistance syndrome, muscarinic and alpha2-adrenergic mediated relaxations were studied in the fructose-fed rat. Male Sprague-Dawley rats were fed either fructose-rich chow (FFR, n=14) or normal chow (CNT, n=13) for 8 weeks.
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