B1883
联苯胺
ISOPAC®, ≥98.0% (N)
别名:
4,4′-二氨基联苯
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关于此项目
经验公式（希尔记法）:
C12H12N2
化学文摘社编号:
分子量:
184.24
UNSPSC Code:
12352200
NACRES:
NA.25
PubChem Substance ID:
EC Number:
202-199-1
Beilstein/REAXYS Number:
742770
MDL number:
产品名称
联苯胺, ISOPAC®, ≥98.0% (N)
InChI key
HFACYLZERDEVSX-UHFFFAOYSA-N
InChI
1S/C12H12N2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8H,13-14H2
SMILES string
Nc1ccc(cc1)-c2ccc(N)cc2
assay
≥98.0% (N)
form
powder
Gene Information
human ... UGT1A4(54657)
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Application
Benzidine (4,4′-Diaminobiphenyl) is an environmental genotoxin that posses increased risks of cancer to exposed people. Benzidine may be used as a reference material in procedures that analyze for benzidine. Benzidine can be used in studies on its mechanisms of genotoxicity.
Biochem/physiol Actions
Tumor initiator in mammalian liver and urinary bladder.
Disclaimer
OSHA′s Safety and Health Standard 29 CFR 1910 does not apply to a solution or mixture containing less than 0.1%. Injecting a compatible solvent permits preparation of any desired strength solution without exposure to benzidine.
Packaging
Packaged in a 100 mL serum bottle with butyl rubber stopper and aluminum tear seal.
Preparation Note
Dissolving the contents in 100 mL of solvent yields a 0.1% solution.
Legal Information
Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
监管及禁止进口产品
此项目有
Hua Ling et al.
Biochemical and biophysical research communications, 401(4), 521-526 (2010-09-30)
Despite the significant role of S-ribosylhomocysteinase (LuxS) in the activated methyl cycle pathway and quorum sensing, the connectivity between luxS and other cellular functions remains incomplete. Herein, we show that luxS deletion significantly increases swimming motility and flagella synthesis in
Brian J Pak et al.
PLoS neglected tropical diseases, 8(8), e3002-e3002 (2014-08-08)
Strongyloidiasis is a persistent human parasitic infection caused by the intestinal nematode, Strongyloides stercoralis. The parasite has a world-wide distribution, particularly in tropical and subtropical regions with poor sanitary conditions. Since individuals with strongyloidiasis are typically asymptomatic, the infection can
P D Josephy
Federation proceedings, 45(10), 2465-2470 (1986-09-01)
Benzidine oxidative activation may proceed by peroxidase-catalyzed one-electron oxidation via free radical intermediates, or by N-acetylation followed by monooxygenase-catalyzed N-hydroxylation. The peroxidase route has been examined by using horseradish peroxidase or prostaglandin H synthase in vitro. In the presence of
G Choudhary
Chemosphere, 32(2), 267-291 (1996-01-01)
Benzidine, an odorless, white to slightly reddish-white crystalline organic compound, is an environmental contaminant that has been identified at about 30 National Priorities List (NPL) hazardous waste sites in the United States. In the environment, it is usually found attached
J Whysner et al.
Pharmacology & therapeutics, 71(1-2), 107-126 (1996-01-01)
The aromatic amine benzidine (BZ) has produced various tumors, including liver tumors, in mice, rats and hamsters. BZ forms DNA adducts in rodent liver, and it is positive in most genotoxicity tests. Only bladder tumors are produced in dogs and
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Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
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