B2559
B581
>95% (HPLC), solid
别名:
N-[2(S)-(2(R)-2-Amino-3-mercaptopropylamino)-3-methylbutyl]-L-phenylalanyl-L-methionine trifluoroacetate salt
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关于此项目
经验公式（希尔记法）:
C22H38N4O3S2
化学文摘社编号:
分子量:
470.69
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
MDL number:
InChI key
QISLMXIYRQCLIR-FUMNGEBKSA-N
SMILES string
CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC[C@@H](NC[C@@H](N)CS)C(C)C)C(O)=O
InChI
1S/C22H38N4O3S2/c1-15(2)20(24-12-17(23)14-30)13-25-19(11-16-7-5-4-6-8-16)21(27)26-18(22(28)29)9-10-31-3/h4-8,15,17-20,24-25,30H,9-14,23H2,1-3H3,(H,26,27)(H,28,29)/t17-,18+,19+,20-/m1/s1
assay
>95% (HPLC)
form
solid
composition
Peptide content, ~60%
color
white
solubility
H2O: soluble
storage temp.
−20°C
Gene Information
rat ... Fnta(25318)
Biochem/physiol Actions
Stable and membrane permeable inhibitor of farnesyltransferase.
Packaging
Packaged under nitrogen and with desiccant.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
A Wagle et al.
The Journal of biological chemistry, 273(24), 14968-14974 (1998-06-17)
Glucose-6-phosphate dehydrogenase (G6PDH) controls the flow of carbon through the pentose phosphate pathway and also produces NADPH needed for maintenance of reduced glutathione and reductive biosynthesis. Hepatic expression of G6PDH is known to respond to several dietary and hormonal factors
K Yoshimatsu et al.
Gan to kagaku ryoho. Cancer & chemotherapy, 24(2), 145-155 (1997-01-01)
Posttranslational farnesylation by farnesyltransferase (FTase) is critical for the function of ras oncogene product and FTase has attracted attention as the new target of anticancer agents. B956 and B1352, obtained from the screening of CAAX analog inhibitors of FTase, induced
S Unlu et al.
Journal of cardiovascular pharmacology, 35(2), 341-344 (2000-02-15)
The isoprenoids geranylgeraniol and farnesol are required for lipid modification of several important cellular proteins. In this study the effect of perillyl alcohol (PA), an inhibitor of geranylgeranyl transferase, was examined on proliferation and apoptosis of immortalized human vascular smooth
A M Garcia et al.
The Journal of biological chemistry, 268(25), 18415-18418 (1993-09-05)
The ras protooncogene is involved in regulation of cell growth. Mutations that activate the protein result in uncontrolled cell growth. Ras undergoes a series of posttranslational processing events, the first of which, farnesylation, is crucial for the function of the
Daniel Bakowski et al.
The Journal of physiology, 553(Pt 2), 387-393 (2003-11-05)
In many cell types, the emptying of intracellular Ca2+ stores results in the opening of store-operated Ca2+ channels in the plasma membrane. However, the nature of the signal that couples store content to the opening of these Ca2+ channels is
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