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B3061

Borrelidin

From Streptomyces parvulus, ≥98% (HPLC), angiogenesis inhibitor, powder

别名:

2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)-cyclopentanecarboxylic acid, Borrelidine, Cyclopentanecarboxylic acid, NSC 216128, Treponemycin

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关于此项目

经验公式（希尔记法）:
C28H43NO6
化学文摘社编号:
7184-60-3
分子量:
489.64
UNSPSC Code:
12352200
PubChem Substance ID:
24724417
NACRES:
NA.77
MDL number:
MFCD01740784
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
200
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产品名称

Borrelidin, from Streptomyces parvulus, ≥98% (HPLC)

biological source

Streptomyces parvulus

Quality Level

200

assay

≥98% (HPLC)

form

powder

solubility

DMSO: 1 mg/mL, methanol: 1 mg/mL

antibiotic activity spectrum

viruses

mode of action

enzyme | inhibits

shipped in

wet ice

storage temp.

−20°C

SMILES string

[H][C@]1(CCC[C@H]1C(O)=O)[C@@H]2C\C=C\C=C(C#N)[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O2

InChI

1S/C28H43NO6/c1-17-12-18(2)14-20(4)27(32)21(16-29)8-5-6-11-25(22-9-7-10-23(22)28(33)34)35-26(31)15-24(30)19(3)13-17/h5-6,8,17-20,22-25,27,30,32H,7,9-15H2,1-4H3,(H,33,34)/b6-5+,21-8-/t17-,18+,19-,20-,22+,23+,24-,25-,27+/m0/s1

InChI key

OJCKRNPLOZHAOU-UGKRXNSESA-N

相关类别

General description

Chemical structure: macrolide

Biochem/physiol Actions

Borrelidin is a potent angiogenesis inhibitor that induces apoptosis in capillary tube-forming cells. Also displays antimalarial activity against drug-resistant Plasmodia. Antimicrobial and selective threonyl t-RNA synthetase inhibitor.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000445517
0000445517
0000380061
0000354271
0000380061

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Carlos Olano
The Journal of antibiotics, 64(1), 51-57 (2010-11-11)
Professor Charles Richard Hutchinson (Hutch) dedicated his research to the study of polyketide compounds, in particular, those produced by actinomycetes. Hutch principally centered his efforts to study the biosynthesis of bioactive compounds, antibiotic and antitumor drugs, and to develop new
András Jeney et al.
Magyar onkologia, 50(2), 93-100 (2006-08-05)
Further progress in the therapy of malignant diseases is expected from the introduction of potent antimetastatic drugs. Surveying of the complex and multi-step behavior of the metastatic process, compounds showing inhibitory action against tumor cell migration may be ranked among
Zhisheng Cao et al.
Bioscience, biotechnology, and biochemistry, 76(2), 353-357 (2012-02-09)
Streptomyces species strain GK18, isolated in Iran, induced deep-pitted lesions on potato tubers, lesions different from the raised lesions induced by the usual scab-causing phytotoxin, thaxtomin. In addition, neither thaxtomin production nor hybridization to its biosynthetic probe was detected for
Carlos Olano et al.
Molecular microbiology, 52(6), 1745-1756 (2004-06-10)
The 18-membered polyketide macrolide borrelidin exhibits a number of important biological activities, including potent angiogenesis inhibition. This has prompted two recent total syntheses as well as the cloning of the biosynthetic gene cluster from Streptomyces parvulus Tü4055. Borrelidin possesses some
Chongxi Liu et al.
International journal of systematic and evolutionary microbiology, 63(Pt 3), 1030-1036 (2012-06-19)
A borrelidin-producing actinomycete, designated strain NEAU-W2(T), was isolated from the root surface of soybean [Glycine max (L.) Merr] and characterized using a polyphasic approach. The organism was found to have morphological and chemotaxonomic characteristics typical of streptomycetes. The G+C content
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全球贸易项目编号

货号GTIN
B3061-1MG04061826128688

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