biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
BOB78, monoclonal
form
buffered aqueous solution
mol wt
antigen ~90 kDa
species reactivity
mouse, human, monkey
concentration
~1 mg/mL
technique(s)
dot blot: suitable, flow cytometry: 1-2 μg/mL using 1x106 THP-1 cells treated with 3 μM camptothecin, immunocytochemistry: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CDH23(64072)
mouse ... Cdh23(22295)
General description
The clearance of neutrophils that appear in large numbers at the inflammatory site is carried out by programmed cell death (apoptosis). An apoptotic neutrophil undergoes several changes in the amount of protein, carbohydrates and lipids. These changes are recognized by macrophages, which thus destroy the neutrophils by phagocytosis. BOB78, with a molecular mass of 90 kDa, is an up-regulated protein that appears in the granular compartment of the late apoptotic neutrophil. This protein does not appear in freshly isolated erythrocytes, platelets, lymphocytes, monocytes, or neutrophils.
Immunogen
serum-deprived THP-1 cells.
Application
Monoclonal Anti-BOB78 antibody produced in mouse is suitable for use in several immunochemical techniques such as immunoblotting, immunocytochemistry, dot-blot and flow cytometry. Monoclonal antibodies specific for BOB78 are useful for studying the biology of apoptotic neutrophils.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
A G Lowrie et al.
British journal of cancer, 94(11), 1663-1671 (2006-05-11)
Proteolysis-inducing factor, a cachexia-inducing tumour product, is an N-glycosylated peptide with homology to the unglycosylated neuronal survival peptide Y-P30 and a predicted product of the dermcidin gene, a pro-survival oncogene in breast cancer. We aimed to investigate whether dermcidin is
S P Hart et al.
Cell death and differentiation, 7(5), 493-503 (2000-05-09)
We have used a panel of monoclonal antibodies and lectins to examine the profile of surface molecule expression on human neutrophils that have undergone spontaneous apoptosis during in vitro culture. Neutrophil apoptosis was found to be accompanied by down-regulation of
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