biological source
human
recombinant
expressed in HEK 293 cells
assay
>95% (SDS-PAGE)
form
lyophilized powder
mol wt
~40 kDa by SDS-PAGE (reducing)
storage condition
avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)
solubility
water: soluble
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... TNFRSF17(608)
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Biochem/physiol Actions
BCMA, a member of the TNF receptor superfamily, binds to the TNF ligands, APRIL and BAFF. It stimulates the production of IgM in peripheral blood B cells and increases survival of cultured B cells.
Member of the TNF receptor superfamily; binds to the TNF ligands, APRIL and BAFF; stimulates the production of IgM in peripheral blood B cells and increases survival of cultured B cells.
The extracellular domain (amino acids 2-54) of human BCMA is fused to the Fc portion of human IgG.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Analysis Note
Inhibits BAFF- and April-mediated B cell activation. May be used to detect cell surface BAFF by flow cytometry.
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