生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
5B7, monoclonal
表单
buffered aqueous solution
分子量
antigen 21 kDa (and possibly a dimer of 42 kDa)
种属反应性
mouse
请勿与下列物质发生反应
rat, human
浓度
2 mg/mL
技术
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 1-5 μg/mL using mouse fibroblast 3T3 cell extract
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
mouse ... Bax(12028)
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免疫原
synthetic peptide corresponding to amino acids 3-16 of the mouse Bax sequence, conjugated to KLH
应用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
生化/生理作用
The epitope recognized by the antibody resides within amino acids 3-16 of the mouse Bax protein.
外形
Solution in phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kate D Sutherland et al.
The EMBO journal, 25(24), 5805-5815 (2006-12-02)
Suppressor of cytokine signalling (SOCS) proteins are critical attenuators of cytokine-mediated signalling in diverse tissues. To determine the importance of Socs3 in mammary development, we generated mice in which Socs3 was deleted in mammary epithelial cells. No overt phenotype was
T W Owens et al.
Cell death and differentiation, 16(11), 1551-1562 (2009-08-08)
Most cells undergo apoptosis through the intrinsic pathway. This is dependent on mitochondrial outer membrane permeabilisation (MOMP), which is mediated by the pro-apoptotic Bcl-2 family proteins, Bax and Bak. During apoptosis, Bax translocates from the cytosol to the outer mitochondrial
Y T Hsu et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(8), 3668-3672 (1997-04-15)
Bcl-2, Bcl-X(L), and Bax are members of the Bcl-2 family that play key roles in the regulation of apoptosis. These proteins are believed to be membrane bound and their ability to undergo both homodimerization and heterodimerization has been proposed to
J-P Upton et al.
Cell death and differentiation, 14(5), 932-942 (2007-02-03)
The Bcl-2 protein Bax normally resides in the cytosol, but during apoptosis it translocates to mitochondria where it is responsible for releasing apoptogenic factors. Using anoikis as a model, we have shown that Bax translocation does not commit cells to
Leilei Zhang et al.
The Journal of pharmacology and experimental therapeutics, 374(2), 308-318 (2020-06-18)
ME-344 is a second-generation cytotoxic isoflavone with anticancer activity promulgated through interference with mitochondrial functions. Using a click chemistry version of the drug together with affinity-enriched mass spectrometry, voltage-dependent anion channels (VDACs) 1 and 2 were identified as drug targets.
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