biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
5B7, monoclonal
form
buffered aqueous solution
mol wt
antigen 21 kDa (and possibly a dimer of 42 kDa)
species reactivity
mouse
should not react with
rat, human
concentration
2 mg/mL
technique(s)
immunoprecipitation (IP): suitable, microarray: suitable, western blot: 1-5 μg/mL using mouse fibroblast 3T3 cell extract
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
mouse ... Bax(12028)
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Immunogen
synthetic peptide corresponding to amino acids 3-16 of the mouse Bax sequence, conjugated to KLH
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
The epitope recognized by the antibody resides within amino acids 3-16 of the mouse Bax protein.
Physical form
Solution in phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Kate D Sutherland et al.
The EMBO journal, 25(24), 5805-5815 (2006-12-02)
Suppressor of cytokine signalling (SOCS) proteins are critical attenuators of cytokine-mediated signalling in diverse tissues. To determine the importance of Socs3 in mammary development, we generated mice in which Socs3 was deleted in mammary epithelial cells. No overt phenotype was
T W Owens et al.
Cell death and differentiation, 16(11), 1551-1562 (2009-08-08)
Most cells undergo apoptosis through the intrinsic pathway. This is dependent on mitochondrial outer membrane permeabilisation (MOMP), which is mediated by the pro-apoptotic Bcl-2 family proteins, Bax and Bak. During apoptosis, Bax translocates from the cytosol to the outer mitochondrial
Y T Hsu et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(8), 3668-3672 (1997-04-15)
Bcl-2, Bcl-X(L), and Bax are members of the Bcl-2 family that play key roles in the regulation of apoptosis. These proteins are believed to be membrane bound and their ability to undergo both homodimerization and heterodimerization has been proposed to
J-P Upton et al.
Cell death and differentiation, 14(5), 932-942 (2007-02-03)
The Bcl-2 protein Bax normally resides in the cytosol, but during apoptosis it translocates to mitochondria where it is responsible for releasing apoptogenic factors. Using anoikis as a model, we have shown that Bax translocation does not commit cells to
L Coultas et al.
Cell death and differentiation, 10(2), 185-192 (2003-04-18)
Proteins of the Bcl-2 family are critical regulators of apoptosis. Proapoptotic members, like Bax, contain three of the four Bcl-2 homology regions (BH1-3), while BH3-only proteins, like Bim, possess only the short BH3 motif. Database searches revealed Bfk, an unusual
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