B9636
S-苯甲酰硫胺 O-单磷酸
别名:
苯磷硫胺
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关于此项目
经验公式（希尔记法）:
C19H23N4O6PS
化学文摘社编号:
分子量:
466.45
NACRES:
NA.79
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
245-013-4
MDL number:
InChI key
BTNNPSLJPBRMLZ-GHRIWEEISA-N
InChI
1S/C19H23N4O6PS/c1-13(23(12-24)11-16-10-21-14(2)22-18(16)20)17(8-9-29-30(26,27)28)31-19(25)15-6-4-3-5-7-15/h3-7,10,12H,8-9,11H2,1-2H3,(H2,20,21,22)(H2,26,27,28)/b17-13+
SMILES string
Cc1ncc(CN(C=O)\C(C)=C(/CCOP(O)(O)=O)SC(=O)c2ccccc2)c(N)n1
assay
≥98% (TLC)
form
powder or crystals
color
white to off-white
storage temp.
2-8°C
Quality Level
Application
S-苯甲酰基硫胺 O-单磷酸酯用于确定其对大鼠骨骼肌缺血和再灌注的影响。
Biochem/physiol Actions
S-苯甲酰基硫胺 O-单磷酸酯（苯磷硫胺）是一种治疗剂。有助于预防视网膜病变、神经病变和肾脏病变等糖尿病并发症。苯磷硫胺抑制糖尿病患者糖基化终末产物（AGE）的合成。苯磷硫胺被认为是预防糖尿病神经病变的营养保健产品。
General description
S-苯甲酰基硫胺 O-单磷酸酯（苯磷硫胺）是两亲性 S-酰基硫胺衍生物。是一种脂溶性维生素。苯磷硫胺含噻唑环。与硫胺素相比，苯磷硫胺具有更高的生物利用度。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Guilherme Vannucchi Portari et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 799-802 (2013-02-02)
Thiamine and benfotiamine are vitamin B1 and pro-vitamin B1 substances, respectively. Vitamin B1 plays an essential role in energy metabolism, and its deficiency leads to neurologic and cardiovascular pathologies, as seen in alcoholics. This study presents new data about the
The multifaceted therapeutic potential of benfotiamine
Balakumar P, et al.
Pharmacological Research, 61(6), 482-488 (2010)
Umesh C S Yadav et al.
Free radical biology & medicine, 48(10), 1423-1434 (2010-03-12)
This study was designed to investigate the molecular mechanisms by which benfotiamine, a lipid-soluble analogue of vitamin B1, affects lipopolysaccharide (LPS)-induced inflammatory signals leading to cytotoxicity in the mouse macrophage cell line RAW264.7. Benfotiamine prevented LPS-induced apoptosis, expression of the
Rajesh Katare et al.
Journal of molecular and cellular cardiology, 49(4), 625-638 (2010-06-15)
Benfotiamine (BFT) is a transketolase activator that directs glucose to the pentose phosphate pathway. The present study investigated whether BFT improves the recovery after myocardial infarction (MI) and explored underlying mechanisms of protection. Non-diabetic and streptozotocin-induced type 1 diabetic mice
Sonia Tarallo et al.
Acta diabetologica, 49 Suppl 1, S141-S151 (2012-04-25)
Pericytes regulate vascular tone, perfusion pressure and endothelial cell (EC) proliferation in capillaries. Thiamine and benfotiamine counteract high glucose-induced damage in vascular cells. We standardized two human retinal pericyte (HRP)/EC co-culture models to mimic the diabetic retinal microvascular environment. We
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