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Merck
CN

BM0008

Sigma-Aldrich

BMS-214662 hydrochloride

≥98% (HPLC)

别名:

(R)-2,3,4,5-Tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-Benzodiazepine-7-carbonitrile monohydrochloride, (R)-7-Cyano-2,3,4,5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3-(phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine hydrochloride, BMS 214662

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关于此项目

经验公式（希尔记法）:
C25H23N5O2S2 · HCl
化学文摘社编号:
195981-08-9
分子量:
526.07
UNSPSC代码:
12352200
PubChem化学物质编号:
329774353

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

H2O: 20 mg/mL, clear

储存温度

room temp

SMILES字符串

O=S(N1CC(C=C(C#N)C=C2)=C2N(CC3=CN=CN3)C[C@H]1CC4=CC=CC=C4)(C5=CC=CS5)=O.[H]Cl

InChI

1S/C25H23N5O2S2.ClH/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22;/h1-11,14,18,23H,12,15-17H2,(H,27,28);1H/t23-;/m1./s1

InChI key

LBPFLNDUCNNGPS-GNAFDRTKSA-N

一般描述

BMS-214662 is a small molecule inhibitor containing an imidazole tetrahydro benzodiazepine and without thiol and peptide attached.

生化/生理作用

BMS-214662 is an orally available, potent and selective inhibitor of farnesyltransferase that reduces Ras prenylation in NF90-8 and ST88-14 sheath tumor (MPNST) cell lines. BMS-214662 induces apoptosis in cancer cell lines, and potently inhibits growth of human tumor xenografts.
BMS-214662 is an orally available, potent and selective inhibitor of farnesyltransferase.
It competes with other inhibitors for Ras protein substrate during inhibition of farnesyltransferase.

特点和优势

BMS-214662 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

法律信息

Sold for research purposes only under agreement from BMS.

储存分类代码

13 - Non Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
076M4731V

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Preclinical antitumor activity of BMS-214662, a highly apoptotic and novel farnesyltransferase inhibitor.
Rose W C, et al.
Cancer Research, 61(20), 7507-7517 (2001)

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