BM0020
BMS-646786
≥98% (HPLC)
别名:
BPTU, N-[2-[2-(1,1-Dimethylethyl)phenoxy]-3-pyridinyl]-N′-[4-(trifluoromethoxy)phenyl]-urea
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关于此项目
经验公式（希尔记法）:
C23H22F3N3O3
化学文摘社编号:
分子量:
445.43
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
protect from light
颜色
white to beige
溶解性
DMSO: 20 mg/mL, clear
储存温度
room temp
SMILES字符串
O=C(NC1=CC=C(OC(F)(F)F)C=C1)NC2=C(OC3=CC=CC=C3C(C)(C)C)N=CC=C2
InChI
1S/C23H22F3N3O3/c1-22(2,3)17-7-4-5-9-19(17)31-20-18(8-6-14-27-20)29-21(30)28-15-10-12-16(13-11-15)32-23(24,25)26/h4-14H,1-3H3,(H2,28,29,30)
InChI key
AHFLGPTXSIRAQK-UHFFFAOYSA-N
生化/生理作用
BMS-646786 is a potent and specific inhibitor of P2Y1 purinergic receptor that inhibits ADP-mediated platelet aggregation in human blood samples. BMS-646786 significantly reduces thrombus weight in a rat arterial thrombosis model with a limited effect on bleeding.
BMS-646786 is a potent and specific inhibitor of P2Y1 purinergic receptor.
特点和优势
BMS-646786 is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.
法律信息
Sold for research purposes only under agreement from BMS.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Chiao-Hsuan Chao et al.
PLoS pathogens, 15(4), e1007625-e1007625 (2019-04-23)
Dengue virus (DENV) infection, the most common mosquito-transmitted viral infection, can cause a range of diseases from self-limiting dengue fever to life-threatening dengue hemorrhagic fever and shock syndrome. Thrombocytopenia is a major characteristic observed in both mild and severe dengue
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