跳转至内容
Merck
CN

BX-0400-30

Human Cortical GABAergic Neurons

new

Human iPSC line, Fully differentiated, Healthy Male Control (no known neurological disorders), Cryopreserved

别名:

Inhibitory Neurons

登录 查看公司和协议定价

选择尺寸

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

生物来源

human (iPSC line)

表单

frozen liquid

包装

vial of 1 (contains ≥1 million cells)

技术

cell culture | mammalian: suitable

储存温度

-140 to -196°C

相关类别

一般描述

Human iPSC-Derived Cortical GABAergic Neurons. Required supplements for the final cell differentiation and maturation (sold separately): BX-2400-100uL, BX-2020-100uL, BX-2040-100uL. Located in the basal forebrain, GABA neurons contain the neurotransmitter gamma-aminobutyric acid (GABA). GABA is an amino acid and the primary inhibitory neurotransmitter for the central nervous system, also known as the CNS. Because GABA reduces neuronal excitability and glutamate increases neuronal excitability, the balance between GABA and glutamate is important for proper neurologic function. Cortical GABAergic neurons can be used to study and understand diseases such as epilepsy, Alzheimer’s disease, and schizophrenia. Primary neurotransmitter released: GABA.

应用

Function: Cortical GABAergic Neurons exhibit pronounced electrophysiological activity after two weeks in culture, as demonstrated on multi-electrode array (MEA) recording systems.

特点和优势

Marker Expression: Fully differentiated Cortical GABAergic Neurons have high neuronal purity (>90%) and comprise predominantly inhibitory neurons. Labeling with the pan-neuronal marker MAP2 (green) and for GABA (red) highlight the purity of this neuronal product. Morphology: Cortical GABAergic Neurons exhibit substantial neurite outgrowth within a week in culture and are adherent. Calcein staining (green) demonstrates the characteristic cell shape and extension of processes of Cortical GABAergic Neurons in culture.

法规信息

新产品
此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our 文件 section.

如需帮助，请联系 客户支持

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Marina Bershteyn et al.
Cell stem cell, 30(10), 1331-1350 (2023-10-07)
Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of patients have drug-refractory seizures and are left with suboptimal therapeutic options such as brain tissue-destructive surgery. Here, we report the development and characterization of a cell therapy

商品

Protocol Guide: Functional Tri-Culture of iPSC-Derived Human Neurons, Astrocytes, and Microglia

Discover an expert protocol for seeding and tri-culturing iPSC-derived neurons, astrocytes, and microglia in monoculture. Explore high purity cells and culture reagents.

Protocol Guide: Cortical GABAergic Neuron Monoculture

Discover an expert protocol for seeding and culturing cortical GABAergic neurons in monoculture. Explore GABAergic neuron culture cells and reagents.

实验方案

Protocol Guide: Spiny Striatal GABAergic Neuron Monoculture

Discover an expert protocol for seeding and culturing spiny striatal GABAergic neuron in monoculture. Explore spiny GABAergic neurons and culture reagents.

Protocol Guide: Astrocytes Monoculture

Discover an expert protocol for seeding and culturing astrocytes in monoculture. Explore high purity astrocytes and culture reagents.

Protocol Guide: Cortical Glutamatergic Neuron Monoculture

Discover an expert protocol for culturing cortical glutamatergic neurons in monoculture. Explore glutamatergic neurons culture cells and reagents.

Protocol Guide: Neuron and Microglia Co-Culture Assay

Discover an expert protocol for seeding and co-culturing iPSC-derived neurons and microglia in monoculture. Explore high purity cells and culture reagents.

查看所有结果

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持