C008
(+)-顺式-二氧戊环
别名:
L-(+)-顺-2-甲基-4-三甲基铵甲基-1,3-二氧戊环碘化物
旋光性
[α]24/D +17.3°, c = 0.5 in H2O(lit.)
颜色
yellow
溶解性
H2O: 10 mg/mL
ethanol: 3 mg/mL
aqueous acid or base: unstable
SMILES字符串
[I-].C[C@H]1OC[C@@H](C[N+](C)(C)C)O1
基因信息
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
生化/生理作用
高亲合性毒蕈碱型乙酰胆碱受体激动剂。
其他说明
经 NMR 测定，该产品为顺式:反式非对映异构体 = 60:40 的混合物。
免责声明
吸湿
法规信息
新产品
A P Ford et al.
European journal of pharmacology, 225(2), 105-112 (1992-02-13)
The muscarinic receptor mediating stimulation of PI hydrolysis in guinea pig atria and ventricles has been studied. The non-selective muscarinic agonist (+)-cis-dioxolane elicited this response, concentration-dependently, with a potency indicative of a low receptor reserve. The potency of a novel
John J Zaunders et al.
Journal of immunology (Baltimore, Md. : 1950), 183(4), 2827-2836 (2009-07-29)
Ag-specific human CD4(+) memory T lymphocytes have mostly been studied using assays of proliferation in vitro. Intracellular cytokine and ELISPOT assays quantify effector cell populations but barely detect responses to certain recall Ags that elicit strong proliferative responses, e.g., tetanus
M Phillippe et al.
Biochemical and biophysical research communications, 231(3), 722-725 (1997-02-24)
These studies sought to determine the intracellular mechanisms underlying muscarinic receptor stimulated phasic contractions of myometrial smooth muscle. Utilizing cytosolic calcium imaging studies with Fura-2 loaded muscle strips, along with in vitro isometric contraction studies, we have demonstrated that phasic
L T Potter et al.
The Journal of pharmacology and experimental therapeutics, 248(3), 974-978 (1989-03-01)
The ability of 16 well-known cholinergic agonists to compete with 1 nM [3H]pirenzepine for the high (KH) and low (KL) affinity states of M1 muscarine receptors was studied, using rabbit hippocampal membranes suspended in 20 mM Tris buffer containing 1
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