C0206
R（+）-SCH-23390 盐酸盐
别名:
R（+）-7-氯-8-羟基-3-甲基-1-苯基-2，3，4，5-四氢-1H-3-苯并氮杂 盐酸盐
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关于此项目
经验公式（希尔记法）:
C17H18ClNO · HCl
化学文摘社编号:
分子量:
324.24
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
Cl[H].CN1CCc2cc(Cl)c(O)cc2[C@H](C1)c3ccccc3
InChI
1S/C17H18ClNO.ClH/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12;/h2-6,9-10,15,20H,7-8,11H2,1H3;1H/t15-;/m1./s1
InChI key
OYCAEWMSOPMASE-XFULWGLBSA-N
Biochem/physiol Actions
Selective D1 dopamine receptor antagonist
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
K M O'Boyle et al.
Journal of neurochemistry, 48(4), 1039-1042 (1987-04-01)
A series of 1-phenyl-1H-3-benzazepine analogues were assessed for enantiomeric and structure-affinity relationships at human putamen D-1 dopamine receptors labelled with [3H]SCH 23390. Substitution at the 7-position of both 3-H and 3-methyl benzazepine molecules critically affected affinity for these receptors over
Katherine E Savell et al.
Science advances, 6(26), eaba4221-eaba4221 (2020-07-09)
Drugs of abuse elevate dopamine levels in the nucleus accumbens (NAc) and alter transcriptional programs believed to promote long-lasting synaptic and behavioral adaptations. Here, we leveraged single-nucleus RNA-sequencing to generate a comprehensive molecular atlas of cell subtypes in the NAc
Nickie Safarian et al.
Scientific reports, 10(1), 9538-9538 (2020-06-14)
Pannexin 1 (Panx1) forms ATP-permeable membrane channels that play roles in the nervous system. The analysis of roles in both standard and pathological conditions benefits from a model organism with rapid development and early onset of behaviors. Such a model