C0290
Clopamide
别名:
4-Chloro-N-(2,6-dimethylpiperidinyl)-3-sulfamoylbenzamide
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关于此项目
经验公式（希尔记法）:
C14H20ClN3O3S
化学文摘社编号:
分子量:
345.84
UNSPSC Code:
41116107
PubChem Substance ID:
EC Number:
211-261-7
MDL number:
InChI key
LBXHRAWDUMTPSE-AOOOYVTPSA-N
InChI
1S/C14H20ClN3O3S/c1-9-4-3-5-10(2)18(9)17-14(19)11-6-7-12(15)13(8-11)22(16,20)21/h6-10H,3-5H2,1-2H3,(H,17,19)(H2,16,20,21)/t9-,10+
SMILES string
C[C@@H]1CCC[C@H](C)N1NC(=O)c2ccc(Cl)c(c2)S(N)(=O)=O
technique(s)
HPLC: suitable, gas chromatography (GC): suitable
format
neat
storage temp.
2-8°C
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Application
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
S Wanwimolruk et al.
Journal of chromatography, 572(1-2), 227-238 (1991-12-06)
A sensitive high-performance liquid chromatographic (HPLC) method for the quantitation of famotidine in human plasma is described. Clopamide was used as the internal standard. Plasma samples were extracted with diethyl ether to eliminate endogenous interferences. Plasma samples were then extracted
C Lengyel et al.
Orvosi hetilap, 138(16), 1003-1006 (1997-04-20)
A case of erythromycin-induced acquired long QT syndrome and "torsades de pointes" ventricular tachycardia is reported. The peculiar ventricular tachyarrhythmia was evoked by orally administered erythromycin (1.5 g/die) in the presence of diuretic (clopamide)-induced hypokalaemia. The pause-dependent "torsades de pointes"
W Stüber et al.
Journal of pharmaceutical sciences, 78(8), 679-682 (1989-08-01)
A gas-liquid chromatography-mass spectroscopy (GLC-MS) method for the determination of clopamide (1) in human plasma was developed to evaluate the pharmacokinetics and bioavailability of 1 in humans. The method is specific, sensitive, and rapid and allows routine analysis as required
L Landriani et al.
Farmaco (Societa chimica italiana : 1989), 44(11), 1059-1068 (1989-11-01)
A series of N-(4-chloro-3-sulfamoylbenzamido)-1,2,3,4-tetrahydroquinoline++ + (IV-1) and isoquinoline (IV-2) have been synthesized and their diuretic and antihypertensive activities evaluated. While none of the test compounds was found to be provided with antihypertensive properties, most of them displayed a diuretic activity
B Krönig et al.
Hypertension (Dallas, Tex. : 1979), 29(2), 651-658 (1997-02-01)
Low-dose combination therapy has been proposed as a rational first-line approach to hypertension treatment. We compared the efficacy and tolerability of the fixed combination of reserpine (0.1 mg) plus the thiazide clopamid (5 mg) with its single components and the
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