Monoclonal Anti-Cytochrome P450 2C6 (CYP2C6) antibody produced in mouse

Cytochrome P450 enzymes are a heme containing mono oxygenase superfamily that in humans are involved in oxidative metabolism of xenobiotics. This metabolism is the initial step in the biotransformation and elimination of a wide variety of drugs and environmental pollutants from the body.

rat liver cytochrome P450 2C6.

Monoclonal Anti-Cytochrome P450 2C6 (CYP2C6) antibody produced in mouse is suitable for indirect ELISA and for western blotting at a concentration of 0.25-0.5mg/mL using rat liver total extract.

Cytochrome P450 enzymes plays an important role in cancer therapy. The rat CYP 2C6 is regarded as a counterpart of human CYP 2C9. CYP2C6 gene is transcriptionally activated in livers of postpubertal rats. In humans, this subfamily is responsible for the metabolism of a variety of therapeutic drugs. Both isoforms specifically catalyze the 4-hydroxylation of diclofenac, phenytoin and warfarin. They can produce 21-hydroxyprogesterone which are inhibited by sulfaphenazole and are induced by phenobarbital.

The antibody reacts with rat CYP 2C6 and human CYP 2C9, as well as other CYP 2C human proteins. It also reacts with phenobarbital-induced CYP 2C proteins in mice. It should be noted that the antibody does not react with human, rat, and mouse CYP 2C8.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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