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Merck
CN

C0884

辅酶 B12

≥97.0%

别名:

5′-脱氧腺苷, DMBC辅酶, 腺苷钴胺, 腺苷钴胺素

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关于此项目

经验公式（希尔记法）:
C72H100CoN18O17P
化学文摘社编号:
13870-90-1
分子量:
1579.58
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
24892282
EC Number:
237-627-6
Beilstein/REAXYS Number:
4122932
MDL number:
MFCD00135609

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产品名称

辅酶 B12, ≥97.0%

InChI key

ZIHHMGTYZOSFRC-PMDPKNCCSA-L

InChI

1S/C62H90N13O14P.C10H12N5O3.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);2-4,6-7,10,16-17H,1H2,(H2,11,12,13);/q;;+2/p-2/t31?,34?,35?,36?,37?,41-,52-,53-,56?,57+,59?,60?,61?,62?;4-,6-,7-,10+;/m11./s1

SMILES string

CC(CNC(=O)CCC1(C)C(CC(N)=O)C2N([Co+]C[C@H]3O[C@@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)C1=C(C)C6=NC(=CC7=NC(=C(C)C8=NC2(C)C(C)(CC(N)=O)C8CCC(N)=O)C(C)(CC(N)=O)C7CCC(N)=O)C(C)(C)C6CCC(N)=O)OP([O-])(=O)O[C@H]9[C@@H](O)[C@H](O[C@@H]9CO)n%10cnc%11cc(C)c(C)cc%10%11

assay

≥97.0%

form

powder and chunks

technique(s)

HPLC: suitable

color

red to very dark red
very dark red-brown

storage temp.

−20°C

Quality Level

100

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相关类别

Application

在yvrC-lacZ 融合的体内检测中，辅酶 B12可用作质粒变种培养的增补剂。

Biochem/physiol Actions

维生素B12（钴胺素）参与DNA合成和脂肪酸合成。 作为一种辅酶，它也在线粒体甲基丙二酰基辅酶A转化为琥珀酰辅酶A的过程中起关键作用。

General description

维生素B12 （钴胺素）是指一组化学上相关的含钴分子。维生素B12的生理活性形式包括甲钴胺和腺苷钴胺素，而羟钴胺素（维生素12a，OHCb1）和氰钴胺素（CNCb1）是其储存和递送的形式。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
WXBF5011V
0000175013
0000151495
0000151494
0000151496

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Coenzyme B12 riboswitches are widespread genetic control elements in prokaryotes
Nahvi A, et al.
Nucleic Acids Research, 32(1), 143-150 (2004)
Radical carbon skeleton rearrangements: catalysis by coenzyme B12-dependent mutases.
Ruma Banerjee
Chemical reviews, 103(6), 2083-2094 (2003-06-12)
Claire Chatelle et al.
ACS synthetic biology, 7(5), 1349-1358 (2018-04-11)
The ever-increasing complexity of synthetic gene networks and applications of synthetic biology requires precise and orthogonal gene expression systems. Of particular interest are systems responsive to light as they enable the control of gene expression dynamics with unprecedented resolution in
Peter Friedrich et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 18(50), 16114-16122 (2012-10-20)
Coenzyme B(12) can assist radical enzymes that accomplish the vicinal interchange of a hydrogen atom with a functional group. It has been proposed that the Co-C bond homolysis of coenzyme B(12) to cob(II)alamin and the 5'-deoxyadenosyl radical is aided by hydrogen bonding
J R Roth et al.
Annual review of microbiology, 50, 137-181 (1996-01-01)
This review examines deoxyadenosylcobalamin (Ado-B12) biosynthesis, transport, use, and uneven distribution among living forms. We describe how genetic analysis of enteric bacteria has contributed to these issues. Two pathways for corrin ring formation have been found-an aerobic pathway (in P.
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