生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 38 kDa
种属反应性
mouse, human
技术
immunoprecipitation (IP): 5 μg using 20 μg of a human A431 cell lysate
microarray: suitable
western blot: 1:1,000-1:5,000 using using human A431 and human Raji cell lysate, respectively
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... CRKL(1399)
mouse ... Crkl(12929)
一般描述
CrkL is a 39kD adaptor protein plays a crucial role in the early steps of IL-2 signal transduction. It also facilitates signaling of β-integrin, B-cell or T-cell receptors. Anti-Crk-L antibody can be used in immunoprecipitation for detecting and localizing CrkL. Rabbit anti-Crk-L antibody reacts specifically with CrkL (38 kD) of human.
免疫原
A synthetic peptide corresponding to amino acids 283-303 of human Crk-L, conjugated to KLH. The sequence is highly conserved in mouse Crk-L (single amino acid substitution).
应用
Anti-Crk-L antibody can be used in western blotting (diluted 1: 1000, 1:5000) using human epidermal carcinoma A431 cell line and Burkitt lymphoma Raji cell line.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
F Gesbert et al.
The Journal of biological chemistry, 273(7), 3986-3993 (1998-03-28)
Interleukin (IL)-2, a major growth and differentiation factor for T lymphocytes, was found to induce tyrosine phosphorylation of the proto-oncogene products p120-Cbl and CrkL in IL-2-dependent cell lines. We established that, in unstimulated lymphocytes, the Src homology 2 (SH2) and
M Sattler et al.
Leukemia, 12(5), 637-644 (1998-05-21)
CRKL is a 39 kDa adapter protein, originally cloned in proximity to the BCR gene on chromosome 22, which has a key regulatory role in hematopoietic cells. CRKL has one SH2 and two SH3 domains, with 60% homology to CRK
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