C0979
抗-过氧化氢酶抗体，小鼠单克隆 小鼠抗
clone CAT-505, purified from hybridoma cell culture
别名:
Anti-CAT
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关于此项目
Conjugate:
unconjugated
Clone:
CAT-505, monoclonal
Application:
immunocytochemistry
immunohistochemistry
indirect ELISA
microarray
western blot
immunohistochemistry
indirect ELISA
microarray
western blot
Species reactivity:
human, mouse, bovine, rat
Citations:
83
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.5-1 μg/mL using a whole extract of HepG2 cells
immunohistochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.5-1 μg/mL using a whole extract of HepG2 cells
Uniprot accession no.:
产品名称
抗-过氧化氢酶抗体，小鼠单克隆 小鼠抗, clone CAT-505, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
CAT-505, monoclonal
form
buffered aqueous solution
mol wt
antigen 60 kDa
species reactivity
human, mouse, bovine, rat
concentration
~2 mg/mL
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.5-1 μg/mL using a whole extract of HepG2 cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CAT(847)
mouse ... Cat(12359)
rat ... Cat(24248)
Application
小鼠抗过氧化氢酶单克隆抗体适用于：
- 免疫组化
- 免疫组织化学
- 间接ELISA
- 微阵列
- 蛋白印迹，浓度为0.5-1μg/mL，使用HepG2细胞全提取物
- 免疫荧光
成功使用该抗体的应用以及相关同行评审论文如下所示。
免疫印迹（5 篇论文）
免疫印迹（5 篇论文）
Biochem/physiol Actions
过氧化氢酶与活性氧过氧化氢反应，使其分解为水和分子氧，它还与氢供体反应。它是一种天然抗氧化剂，保护细胞免受蛋白质、脂质和核酸的氧化损伤。过氧化氢酶还在基因表达和细胞凋亡中发挥作用。抗氧化剂已被鉴定与多种细胞功能有关，包括生长控制、增殖、分化、免疫反应、肿瘤促进、细胞凋亡和病毒活化。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
过氧化氢酶是几乎所有暴露在氧气中的生物体中发现的最高效和最常见的酶之一。它是一种非常重要的酶，可以保护细胞免受活性氧（ROS）的氧化损伤。在大多数哺乳动物细胞中，过氧化氢酶位于过氧化物酶体中，过氧化物酶是一种四聚体氯化血红素酶，由4个相同的60kDa的亚基四面体排列而成。分子量为240 kDa，每个分子中含有四个铁原卟啉基团。
Immunogen
人红细胞过氧化氢酶
Physical form
0.01 M 磷酸盐缓冲液 (pH 7.4) 中的溶液，含 15 mM 叠氮化钠
Preparation Note
从生物反应器中的杂交瘤细胞培养物上清液中纯化获得。
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Kisuk Min et al.
Skeletal muscle, 7(1), 21-21 (2017-10-20)
The mitogen-activated protein kinases (MAPKs) have been shown to be involved in regulating myofiber survival. In skeletal muscle, p38 MAPK and JNK are negatively regulated by MAPK phosphatase-5 (MKP-5). During muscle regeneration, MKP-5 is downregulated, thereby promoting p38 MAPK/JNK signaling
The curious case of peroxiredoxin-5: what its absence in aves can tell us and how it can be used
Pirson M, et al.
BMC Evolutionary Biology, 18(1), 18-18 (2018)
P Chelikani et al.
Cellular and molecular life sciences : CMLS, 61(2), 192-208 (2004-01-28)
More than 300 catalase sequences are now available, divided among monofunctional catalases (> 225), bifunctional catalase-peroxidases (> 50) and manganese-containing catalases (> 25). When combined with the recent appearance of crystal structures from at least two representatives from each of
J M Matés et al.
Frontiers in bioscience : a journal and virtual library, 4, D339-D345 (1999-03-17)
Aerobic organisms possess antioxidant defense systems that deal with reactive oxygen species (ROS) produced as a consequence of aerobic respiration. Reactive oxygen is related to both, the arrest of growth and the start of cell differentiation. Low concentrations of reactive
E C Kaal et al.
Journal of neuroscience research, 54(6), 778-786 (1998-12-18)
Evidence is growing that reactive oxygen species (ROS), by-products of (normal) cellular aerobic metabolism, are involved in the pathogenesis of neurodegenerative diseases. One of these diseases is amyotrophic lateral sclerosis (ALS), in which motoneurons die, leading to paralysis and death.
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