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C1055

Cromakalim

Name: Cromakalim
Brand: SIGMA

别名:

(±)-trans-6-Cyano-3,4-dihydro-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-3-ol

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₈N₂O₃

化学文摘社编号:

94470-67-4

分子量:

286.33

NACRES:

NA.77

PubChem Substance ID:

24891962

UNSPSC Code:

12352200

MDL number:

MFCD00133201

Form:

powder

Quality level:

200

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属性

form

powder

Quality Level

200

storage temp.

2-8°C

SMILES string

CC1(C)Oc2ccc(cc2[C@H]([C@@H]1O)N3CCCC3=O)C#N

InChI

1S/C16H18N2O3/c1-16(2)15(20)14(18-7-3-4-13(18)19)11-8-10(9-17)5-6-12(11)21-16/h5-6,8,14-15,20H,3-4,7H2,1-2H3/t14-,15+/m1/s1

InChI key

TVZCRIROJQEVOT-CABCVRRESA-N

Gene Information

rat ... Kcna1(24520), Kcnj1(24521), Kcnj5(29713), Kcnj8(25472)

说明

Application

Cromakalim has been used:

as a potassium channel agonist to study its response to an acute increase in downstream pressure in rat lymphatic vessels.
as a potassium channel opener to study its effects on the release of transmitters from adrenergic nerves in rat vas deferens.
as a potassium channel activator to study its effects on the release of transmitters from purinergic and cholinergic nerves in the rat detrusor muscle.

Biochem/physiol Actions

Cromakalim is an activator of the potassium channel. It is involved in the relaxation of the vascular smooth muscles. Cromakalim exhibits anti-hypertensive activity.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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BRL 34915 (cromakalim) activates ATP-sensitive K+ current in cardiac muscle.

M C Sanguinetti et al.

Proceedings of the National Academy of Sciences of the United States of America, 85(21), 8360-8364 (1988-11-01)

The mechanism by which the antihypertensive agent BRL 34915 (cromakalim) affects action potential duration (APD) and effective refractory period (ERP) in isolated cardiac muscle was investigated. BRL 34915 (greater than or equal to 3 microM) shortened ERP of ferret (Mustela

Vasorelaxant effects of cromakalim in rats are mediated by glibenclamide-sensitive potassium channels.

Cavero I, et al.

Journal of Pharmacology and Experimental Therapeutics, 248(3), 1261-1268 (1989)

Evaluation of the potassium channel activator levcromakalim (BRL38227) on the lipid profile, electrolytes and blood glucose levels of streptozotocin-diabetic rats.

Omonkhelin J Owolabi et al.

Journal of diabetes, 5(1), 88-94 (2013-02-05)

Levcromakalim is a vasorelaxant used in the management of hypertension in diabetes mellitus. Thus, the effects of levcromakalim were investigated in streptozotocin (STZ)-diabetic rats. Diabetes was induced in Wistar albino rats with a single injection of STZ (60 mg/kg, i.p.)

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全球贸易项目编号

货号	GTIN
C1055-50MG	04061832574059
C1055-10MG	04061832574042