Anti-CXCR3 antibody produced in rabbit

Chemokines bind to specific G protein-coupled cell surface receptors on target cells. Five CXC receptors (CXCR1-5), nine CC receptors (CCR1-9) and one CXXXC receptor (CX3CR1) have been cloned to date. Expression of chemokine receptors can be restricted to some cell types (CXCR1 is expressed in neutrophils) while others (such as CCR2) are expressed in a wide variety of cells. CXCR-3, also known as the IP-10/Mig receptor, shares approximately 40% protein sequence idENTITY_TYPE_CODE with CXCR-1 and CXCR-2, and 34.2-36.9% amino acid sequence idENTITY_TYPE_CODE with the five known CC chemokine receptors 1-5. CXCR-3 is highly expressed by IL-2-activated T lymphocytes (Th1), but not by resting T lymphocytes, B lymphocytes, monocytes or granulocytes. CXCR-3 binds IP-10 and Mig (but not PF4) with high affinity and mediates Ca²⁺ mobilization and chemotaxis. CXCR-3 does not bind any of the CXC chemokines containing the ELR motif. CXCR3 expression has been documented in the brain, lymphoid and other peripheral tissues, and in diseases including atheroslerosis, Alzheimer′s, multiple sclerosis, rheumatoid arthritis, lymphomas, asthma, neoplasms, leukemia, and inflammatory conditions of various organs.

Rabbit polyclonal anti-CXCR3 antibody specifically recognizes human CXC Chemokine Receptor 3 by immunohistochemistry with formalin-fixed, paraffin embedded tissues. Not tested for other uses. The immunizing peptide has 82% homology with the rat and mouse gene. Other species reactivity has not been confirmed.

synthetic peptide corresponding to the C-terminus of human CXC chemokine receptor 3 (CXCR3), conjugated to KLH. The immunizing peptide has 82% homology with the rat and mouse gene.

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Rabbit polyclonal anti-CXCR3 antibody is used to tag CXC Chemokine Receptor 3 for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques. It is used as a probe to determine the presence and roles of CXC Chemokine Receptor 3 in processes such as the mediation of Ca²⁺ mobilization and chemotaxis.

Solution in phosphate buffered saline containing 0.1% sodium azide.

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