C156
D-CPT tartrate
>94%, solid
别名:
β-CPT tartrate, (–)-2β-Carbomethoxy-3β-phenyltropane tartrate, Troparil tartrate, WIN 35,065-2
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关于此项目
经验公式（希尔记法）:
C16H21NO2 · C4H6O6
化学文摘社编号:
分子量:
409.43
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
Assay:
>94%
Form:
solid
assay
>94%
form
solid
optical activity
[α]22/D −95.9°, c = 1.1 in H2O(lit.)
drug control
USDEA Schedule II; Home Office Schedule 2; regulated under CDSA - not available from Sigma-Aldrich Canada
color
white
solubility
H2O: soluble, ethanol: soluble
storage temp.
−20°C
SMILES string
OC(C(O)C(O)=O)C(O)=O.COC(=O)[C@@H]1C2CCC(C[C@@H]1c3ccccc3)N2C
InChI
1S/C16H21NO2.C4H6O6/c1-17-12-8-9-14(17)15(16(18)19-2)13(10-12)11-6-4-3-5-7-11;5-1(3(7)8)2(6)4(9)10/h3-7,12-15H,8-10H2,1-2H3;1-2,5-6H,(H,7,8)(H,9,10)/t12-,13+,14+,15-;/m0./s1
InChI key
WYGLYLVLBCZESH-PEVLCXCCSA-N
Biochem/physiol Actions
Binds to the cocaine receptor site on the dopamine transporter and blocks dopamine uptake.
Features and Benefits
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Disclaimer
Hygroscopic
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Emily M Jutkiewicz et al.
Annals of emergency medicine, 54(3), 409-420 (2008-11-18)
Cocaine toxicity results in cardiovascular complications, seizures, and death and accounts for approximately 20% of drug-related emergency department visits every year. Presently, there are no treatments to eliminate the toxic effects of cocaine. The present study hypothesizes that a bacterial
M E Reith
European journal of pharmacology, 130(1-2), 65-72 (1986-10-14)
Cocaine and a cocaine analog, WIN 36,065-2, were administered daily for 3 or 4 days. Both compounds developed sensitization to their locomotor stimulatory effects, with similarly shaped dose-response curves. Dosages giving optimal sensitization were 25 mg/kg per day for cocaine
Potent cocaine analogs inhibit [3H]dopamine uptake in rat mesencephalic cells in primary cultures: pharmacological selectivity of embryonic cocaine sites.
Brouard, A., et al.
Brain Research, 75, 13-17 (1993)
A Brouard et al.
Brain research. Developmental brain research, 75(1), 13-17 (1993-09-17)
The cellular localization of the cocaine binding sites in primary cultures of embryonic rat mesencephalic cells was previously reported to differ from that observed in adult rat brain. In order to know whether this different localization was associated with a
B Aronson et al.
Journal of medicinal chemistry, 39(7), 1560-1563 (1996-03-29)
The transition metal complexes [eta(6)- (2beta-carbomethoxy-3beta-phenyltropane)]tricarbonylchromium (3) and [eta(6)-(2beta-carbomethoxy-3beta-phenyltropane)] [eta(5)-(pentamethylcyclopentadienyl)]ruthenium(II)triflate (4) were synthesized from 2beta-carbomethoxy-3beta-phenyltropane (2, WIN 35,065) to further elucidate the influence of substituents on the 3beta-aryl on the affinity of the ligand for cocaine-binding sites at the dopamine
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| C156-5MG | 04061832269825 |
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