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Merck
CN

C1613

羧苄西林

Ready Made Solution, 100 mg/mL in ethanol/water

别名:

α-羧苄青霉素 溶液

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关于此项目

经验公式（希尔记法）:
C17H18N2O6S
分子量:
378.40
NACRES:
NA.85
PubChem Substance ID:
24892425
UNSPSC Code:
51282404
MDL number:
MFCD00242604

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产品名称

羧苄西林, Ready Made Solution, 100 mg/mL in ethanol/water

InChI key

FPPNZSSZRUTDAP-UWFZAAFLSA-N

SMILES string

CC1(C)S[C@@H]2[C@H](NC(=O)C(C(O)=O)c3ccccc3)C(=O)N2[C@H]1C(O)=O

InChI

1S/C17H18N2O6S/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25)/t9?,10-,11+,14-/m1/s1

form

liquid
ready-to-use solution

concentration

100 mg/mL in ethanol/water

solubility

H2O: 100 mg/mL
ethanol: 100 mg/mL

suitability

suitable for testing specifications (Bacteriostatic (cell type) E. Coli DH5a, result: pass)

antibiotic activity spectrum

Gram-negative bacteria
Gram-positive bacteria

mode of action

cell wall synthesis | interferes

shipped in

wet ice

storage temp.

−20°C

Quality Level

200

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相关类别

Application

羧苄青霉素(Carbenicillin)可用于筛选氨苄青霉素抗性转化细胞。还可用于研究青霉素敏感的转肽酶在细胞壁生物合成中的作用。

Biochem/physiol Actions

羧苄西林(Carbenicillin)是一种氨苄西林类似物，具有苄基青霉素结构。羧苄西林可有效抑制革兰氏阴性菌，对革兰氏阳性菌也有一定的抑制作用。羧苄西林结合并抑制参与细菌细胞壁合成的酶。由于羧苄西林对β-内酰胺酶的敏感性弱于氨苄西林，它可有效抑制氨苄西林抗性细菌。在低pH条件下具有优越的稳定性，可发挥筛选功能。 羧苄西林的有效浓度：50-100 μg/ml。

General description

化学结构:β-内酰胺

Other Notes

保持容器密闭，并置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。

pictograms

FlameHealth hazard
GHS02,GHS08

signalword

Danger

Hazard Classifications

Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1

存储类别

3 - Flammable liquids

wgk

WGK 2

flash_point_f

104.0 °F - closed cup

flash_point_c

40 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000366369
0000209011
0000366369
0000209011
0000161550

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Andrea Brenna et al.
AMB Express, 4, 43-43 (2014-06-21)
Agrobacterium tumefaciens-mediated transformation is a powerful tool for reverse genetics and functional genomic analysis in a wide variety of plants and fungi. Tuber spp. are ecologically important and gastronomically prized fungi ("truffles") with a cryptic life cycle, a subterranean habitat
G N Rolinson
The Journal of antimicrobial chemotherapy, 41(6), 589-603 (1998-08-01)
For more than 40 years the author has been involved in research in the field of beta-lactam antibiotics. Much of this work was concerned with the development of the semisynthetic penicillins, following the isolation of the penicillin nucleus, 6-aminopenicillanic acid.
A J Wright
Mayo Clinic proceedings, 74(3), 290-307 (1999-03-25)
The penicillin family of antibiotics remains an important part of our antimicrobial armamentarium. In general, these agents have bactericidal activity, excellent distribution throughout the body, low toxicity, and efficacy against infections caused by susceptible bacteria. The initial introduction of aqueous
Maria Tomás et al.
Antimicrobial agents and chemotherapy, 54(5), 2219-2224 (2010-03-03)
Expression of ampC, oprD, mexA, mexC, mexE, and mexX was studied in 25 Pseudomonas aeruginosa isolates from cystic fibrosis patients, including 14 isolates of the Liverpool epidemic strain. Overexpressed mexA or ampC and reduced oprD were associated with beta-lactam resistance.
Kunihiko Nishino et al.
Antimicrobial agents and chemotherapy, 54(5), 2239-2243 (2010-03-10)
NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In this study, we report that overproduction of NlpE increases multidrug and copper resistance through activation of the genes encoding the AcrD and MdtABC multidrug efflux pumps
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