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C1835

(S)-(+)-4-Carboxyphenylglycine

Name: (<I>S</I>)-(+)-4-Carboxyphenylglycine
Brand: SIGMA

别名:

(S)-α-Amino-4-carboxyphenylacetic acid, L-α-(4-Carboxyphenyl)glycine, S-4CPG

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关于此项目

经验公式（希尔记法）:

C₉H₉NO₄

化学文摘社编号:

134052-73-6

分子量:

195.17

UNSPSC Code:

12352103

MDL number:

MFCD00216831

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属性

solubility

0.1 M NaOH: 15 mg/mL

说明

Biochem/physiol Actions

Competitive mGluR₁ metabotropic glutamate receptor antagonist; mGluR₂ metabotropic glutamate receptor agonist.

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

026H0148

089H1383

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Competitive antagonism at metabotropic glutamate receptors by (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine.

S A Eaton et al.

European journal of pharmacology, 244(2), 195-197 (1993-01-15)

Two phenylglycine derivates, (S)-4-carboxyphenylglycine and (RS)-alpha-methyl-4-carboxyphenylglycine, competitively antagonised (1S,3R)-1-aminocyclopentane-1,3-dicarboxylate (ACPD)-stimulated phosphoinositide hydrolysis in rat cerebral cortical slices. The same phenylglycine derivatives selectively antagonized ACPD-induced depolarization in neonatal rat spinal motoneurones and rate thalamic neurones relative to depolarization or excitation induced

Pharmacological analysis of carboxyphenyl-glycines at metabotropic glutamate receptors.

Cavanni, et al.

Eur. J. Pharmacol., Molec. Pharmacol. Sec., 269, 9-9 (1994)

Phenylglycine derivatives as new pharmacological tools for investigating the role of metabotropic glutamate receptors in the central nervous system.

E F Birse et al.

Neuroscience, 52(3), 481-488 (1993-02-01)

The possible roles of G-protein coupled metabotropic glutamate receptors in central nervous function are currently the focus of intensive investigation. The complexity of effects produced by agonists at these receptors probably reflects the activity of a range of sub-types. The