biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~50 kDa
species reactivity
human
technique(s)
western blot: 1:500-1:2,000
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... CA9(768)
General description
Carbonic anhydrase 9 (CA9/CAIX) is an enzyme encoded by the CA9 gene in humans. It is also referred as MN and CAIX. It belongs to Carbonic anhydrases (CAs) family that catalyzes the reversible hydration of carbon dioxide. It is a metalloenzyme that is localized to the membrane. It is involved in pH homeostasis with an effect on regulation of cell proliferation, oncogenesis and tumor progression. MN/CA IX is the only tumor-associated CA isoenzyme located on chromosome band 9p12-p13. It act as a marker for renal cell carcinoma. It is used for patients with advanced mesothelioma. CA9 is useful in differentiating CRCC from ChRCC and oncocytomas, distinguishing low-grade CRCC from normal renal tubules in small samples, separating ICC from HCC and identifying metastatic CRCC from other metastases. Under hypoxia, the CA9 increases, which is related to poor prognostic factors and a functional mediator of cancer progression.
Immunogen
synthetic peptide corresponding to amino acids 131-145 of human CA9
Application
Yale Center for High Throughput Cell Biology IF-tested antibodies. Each antibody is tested by immunofluorescence against HUVEC cells using the Yale HTCB IF protocol. To learn more about us and Yale Center for High Throughput Cell Biology partnership, visit sigma.com/htcb-if. Anti-CA9 (131-145) antibody produced in rabbit is suitable for western blotting at a dilution of 1:500-1:2000.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
Radiation hybrid mapping of the human MN/CA9 locus to chromosome band 9p12-p13.
Y Nakagawa et al.
Genomics, 53(1), 118-119 (1998-10-27)
R Opavský et al.
Genomics, 33(3), 480-487 (1996-05-01)
We have isolated, sequenced, and characterized a human MN/CA9 gene. This gene is a novel member of the carbonic anhydrase (CA) family, which codes for widely distributed catalysts of the reversible conversion of carbon dioxide to carbonic acid. So far
Vijayalakshmi Ananthanarayanan et al.
American journal of clinical pathology, 142(1), 82-87 (2014-06-14)
To examine carbonic anhydrase IX (CAIX), a marker of renal cell carcinoma that recently has been described in malignant effusions. Pleural and peritoneal fluids with the following diagnoses-reactive (n = 23), carcinoma (n = 17), and "suspicious for mesothelioma" (n
Paul C McDonald et al.
Sub-cellular biochemistry, 75, 255-269 (2013-10-23)
The development of hypoxic microenvironments within many types of solid tumors imposes a significant stress on cancer cells to which they must respond appropriately in order to survive and grow. Tumor-specific, hypoxia-induced upregulation of Carbonic Anhydrase IX (CAIX) is a
L Capkova et al.
Neoplasma, 61(2), 161-169 (2014-01-30)
Malignant mesothelioma is an aggressive tumor with a poor prognosis. Carbonic anhydrase IX (CAIX) is a membranously located metalloenzyme involved in pH homeostasis with influence on regulation of cell proliferation, oncogenesis and tumor progression. Much attention has been paid recently
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