form
solid
solubility
H2O: insoluble, ethanol: moderately soluble
SMILES string
Oc1cc2OC(=O)Nc2cc1Cl
InChI
1S/C7H4ClNO3/c8-3-1-4-6(2-5(3)10)12-7(11)9-4/h1-2,10H,(H,9,11)
InChI key
AGLXDWOTVQZHIQ-UHFFFAOYSA-N
Application
氯唑沙宗的 CYP2E1 & 1A2 代谢物。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Ko-Hsiu Lu et al.
Molecules (Basel, Switzerland), 26(1) (2020-12-31)
Osteosarcoma, the most prevalent malignant bone tumor in the pediatric age group, is responsible for the great majority of cancer-associated deaths owing to its highly metastatic potential. The anti-metastatic effects of the new curcumin analogue L48H37 in human osteosarcoma are
Reza Mehvar et al.
Journal of pharmaceutical sciences, 95(7), 1414-1424 (2006-05-26)
The steady-state disposition of chlorzoxazone (CZX) and its hydroxylated metabolite 6-hydroxychlorzoxazone (HCZX) was determined in a single-pass isolated perfused rat liver (IPRL) model using constant CZX concentrations of 10-200 microM. The concentrations of CZX, HCZX, and/or HCZX glucuronide in the
Eva González-Jasso et al.
Toxicology letters, 144(1), 55-67 (2003-08-16)
The inducibility of CYP2E1 was investigated in liver and peripheral lymphocytes of rats treated with benzene (0-10 mmol/kg body weight (bw), daily for 3 days, i.p., or 0 and 5 mmol/kg bw, daily for 14 days, i.p.) or toluene (0
Thomas D Nolin et al.
Clinical pharmacology and therapeutics, 74(6), 555-568 (2003-12-10)
The purposes of this study were (1) to describe the disposition of chlorzoxazone and 6-hydroxychlorzoxazone in patients with kidney disease, (2) to develop a population pharmacokinetic model including covariates that may influence the pharmacokinetic variability of both compounds, and (3)
Won- Suk Chung et al.
Life sciences, 73(3), 253-263 (2003-05-22)
It has been reported from our laboratories that expression of CYP2E1 significantly increased and decreased in rats with acute renal failure induced by uranyl nitrate (U-ARF) treated with recombinant human growth hormone (rGH) for one day (U-ARF1) compared with those
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 573128-10MG | 04055977190182 |
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