C1897
Catechol-O-methyl Transferase from porcine liver
lyophilized powder, ≥150 units/mg protein
别名:
COMT, Pyrocatechol-O-methyl Transferase, S-Adenosyl-L-methionine:catechol O-methyltransferase
表单
lyophilized powder
比活
≥150 units/mg protein
纯化方式
chromatography
组成
Protein, 30-60% biuret
储存温度
−20°C
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生化/生理作用
Major degradative enzyme for catecholamine neurotransmitters; methylates the o-hydroxyl group
外形
Lyophilized powder containing phosphate buffer and dithiothreitol
其他说明
One unit will produce 1.0 nanomole of total O-methylated products from 3,4 dihydroxyacetophenone per hour at pH 7.6 at 37 °C.
Previous radioactive assay unit definition: One unit will catalyze the methylation of 1.0 nanomole of protocatechuic acid per hr at pH 7.9 at 37°C using S-adenosyl-L-[methyl-14C]methionine as the methyl donor. (~6 radioactive units equal one new unit).
Previous radioactive assay unit definition: One unit will catalyze the methylation of 1.0 nanomole of protocatechuic acid per hr at pH 7.9 at 37°C using S-adenosyl-L-[methyl-14C]methionine as the methyl donor. (~6 radioactive units equal one new unit).
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M C Wardle et al.
Genes, brain, and behavior, 12(1), 13-20 (2012-12-13)
In a widely cited study, Mattay et al. reported that amphetamine (0.25 mg/kg oral, or 17 mg for a 68 kg individual) impaired behavioral and brain indices of executive functioning, measured using the Wisconsin Card Sorting Task (WCST) and N-Back
Nidhi Jatana et al.
Journal of molecular graphics & modelling, 39, 145-164 (2013-01-03)
Catechol-O-methyltransferase (COMT) catalyzes the methylation of catecholamines, including neurotransmitters like dopamine, epinephrine and norepinephrine, leading to their degradation. COMT has been a subject of study for its implications in numerous neurological disorders like Parkinson's disease (PD), schizophrenia, and depression. The
Excessive daytime sleepiness and its risk factors in incident Parkinson's disease.
David P Breen et al.
Journal of neurology, neurosurgery, and psychiatry, 84(2), 233-234 (2012-11-28)
Luis Almeida et al.
Clinical pharmacokinetics, 52(2), 139-151 (2012-12-19)
Opicapone is a novel catechol-O-methyltransferase (COMT) inhibitor. The purpose of this study was to evaluate the tolerability, pharmacokinetics (including the effect of food) and pharmacodynamics (effect on COMT activity) following single oral doses of opicapone in young healthy male volunteers.
Francesco Papaleo et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(49), 20160-20165 (2012-11-22)
Cognitive functioning differs between males and females, likely in part related to genetic dimorphisms. An example of a common genetic variation reported to have sexually dimorphic effects on cognition and temperament in humans is the Val/Met polymorphism in catechol-O-methyltransferase (COMT).
相关内容
QC Methods
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