生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
lyophilized powder
种属反应性
rat
技术
immunohistochemistry: suitable
western blot (chemiluminescent): 1:200-1:300
UniProt登记号
储存温度
−20°C
基因信息
rat ... Cacnb3(25297)
免疫原
synthetic peptide corresponding to amino acids 463-477 of the β3 subunit of rat brain voltage-gated calcium channel (VGCC, Caβ3) with additional N-terminal cysteine, conjugated to KLH. This epitope is identical in all known alternative splicing isoforms of Caβ3 in mouse, rat, human, and Xenopus.
外形
Lyophilized at approximately 0.3 mg/ml from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, 5% sucrose and 0.025% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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A Ludwig et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(4), 1339-1349 (1997-02-15)
The neuronal high voltage-activated calcium channels are a family of ion channels composed from up to five different alpha1 and four different beta subunits. The neuronal distribution and subunit composition of calcium channels were investigated using subunit-specific antibodies and riboprobes.
Kayoung Lee et al.
Cell reports, 24(4), 922-934 (2018-07-26)
Voltage-gated Ca2+ channels (Cav) are essential for pancreatic beta cell function as they mediate Ca2+ influx, which leads to insulin exocytosis. The β3 subunit of Cav (Cavβ3) has been suggested to regulate cytosolic Ca2+ ([Ca2+]i) oscillation frequency and insulin secretion
R Hullin et al.
The EMBO journal, 11(3), 885-890 (1992-03-01)
Complementary DNAs encoding three novel and distinct beta subunits (CaB2a, CaB2b and CaB3) of the high voltage activated (L-type) calcium channel have been isolated from rabbit heart. Their deduced amino acid sequence is homologous to the beta subunit originally cloned
Geraldine A Fuller-Bicer et al.
American journal of physiology. Heart and circulatory physiology, 297(1), H117-H124 (2009-05-12)
Cardiac L-type voltage-dependent Ca(2+) channels are heteromultimeric polypeptide complexes of alpha(1)-, alpha(2)/delta-, and beta-subunits. The alpha(2)/delta-1-subunit possesses a stereoselective, high-affinity binding site for gabapentin, widely used to treat epilepsy and postherpetic neuralgic pain as well as sleep disorders. Mutations in
Matthieu Rousset et al.
Neuropharmacology, 97, 201-209 (2015-06-06)
High-Voltage-Activated (HVA) Ca(2+) channels are known regulators of synapse formation and transmission and play fundamental roles in neuronal pathophysiology. Small GTPases of Rho and RGK families, via their action on both cytoskeleton and Ca(2+) channels are key molecules for these
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