C199
CGS-15943
≥98% (HPLC), Adenosine receptor antagonist, solid
别名:
9-Chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine
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关于此项目
经验公式（希尔记法）:
C13H8ClN5O
化学文摘社编号:
分子量:
285.69
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
产品名称
CGS-15943, solid
assay
≥98% (HPLC)
Quality Segment
form
solid
color
white
solubility
DMSO: >10 mg/mL, H2O: insoluble
storage temp.
room temp
SMILES string
Nc1nc2ccc(Cl)cc2c3nc(nn13)-c4ccco4
InChI
1S/C13H8ClN5O/c14-7-3-4-9-8(6-7)12-17-11(10-2-1-5-20-10)18-19(12)13(15)16-9/h1-6H,(H2,15,16)
InChI key
MSJODEOZODDVGW-UHFFFAOYSA-N
Gene Information
human ... ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora2b(29316)
Application
CGS-15943 has been used as a non-selective adenosine receptor antagonist to study its effects on the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and hepatocellular carcinoma (HCC). It has also been used as a non-selective adenosine receptor antagonist to investigate the mechanism underlying adenosine inhibition on cholangiocarcinoma (CCA) cells.
Biochem/physiol Actions
CGS-15943 is a potent and non-selective adenosine receptor antagonist. It exhibits anti-carcinogenic and anti-apoptotic activity.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)